Oncohema Key

♦Vindesine (vin’-de-seen) Eldisine, desacetyl vinblastine Pregnancy Category D Mechanism of Action A vinca alkaloid that binds to tubulin and alters the micro-tubular spindle structure, which leads to cell lysis. Indications…

♦Vincristine (vin-kris’-teen) Oncovin, VCR, Vincasar Pregnancy Category D Mechanism of Action A vinca alkaloid that arrests metaphase by binding microtubule protein to the mitotic spindle. Specific for the S phase….

♦Vinblastine (vin-blas’-teen) Velban, VLB Pregnancy Category D Mechanism of Action A cell cycle-specific vinca alkaloid that inhibits mitotic spindle formation by binding to tubulin. Most specific for the M phase….

♦Uracil Mustard (yoor’-a-sill) Pregnancy Category X Mechanism of Action An alkylating agent that binds to DNA, inhibits DNA synthesis, and leads to cell death. Indications Chronic lymphoblastic leukemia, chronic myelogenous…

♦Tretinoin (tret’-i-noyn) Retinoic acid, Vesanoid Pregnancy Category D Mechanism of Action Not understood. This natural retinoid may play a role in hematopoiesis and immune function. Inhibits the proliferation of acute…

♦Topotecan Hydrochloride (toe-poe’-tee-kan) Hycamtin Pregnancy Category D Mechanism of Action A semisynthetic derivative of camptothecin, topotecan inhibits the activity of topoisomerase I, an enzyme necessary for DNA replication. Indications Metastatic…

♦Thiotepa (thy-oh-tep’-ah) Triethylene, Thio-Tepa, TESPA, TSPA Pregnancy Category D Mechanism of Action An alkylating agent that alters DNA replication, RNA transcription, and nucleic acid formation, resulting in cell death. Indications…

♦Thioguanine (thye-oh-gwah’-neen) TG, 6-thioguanine, Tabloid Pregnancy Category D Mechanism of Action An antimetabolite that inhibits purine synthesis by substituting for the nucleotide guanine. S phase-specific. Indications Acute lymphocyte leukemia, acute…

♦Testolactone (tess-toe-lak’-tone) Teslac Pregnancy Category X Mechanism of Action An androgen estrogen antagonist that impairs tumor growth by suppressing pituitary function. Indications Advanced breast carcinoma, refractory anemia. Metabolism/Excretion Metabolized in…

♦Teniposide (teh-nip’-oh-side) VM-26, Vumon Pregnancy Category D Mechanism of Action A phase-specific drug that causes DNA strand breakage and the inhibition of type II topoisomerase, which leads to cell death….