Cancer Pain: Principles of Assessment and Syndromes
Cancer Pain: Principles of Assessment and Syndromes Nathan I. Cherny Surveys indicate that pain is experienced by 30–60% of patients with cancer during active therapy and by more than two…
Inherited Dyslipoproteinemias of Various Etiologies
Inherited Dyslipoproteinemias of Various Etiologies Familial lipoprotein(a) hyperlipoproteinemia High levels of lipoprotein(a) (Lp(a)) aggregate or segregate in families and may be associated with atherosclerotic vascular disease. In Turkey, a country…
Inherited Mixed Dyslipoproteinemias
Inherited Mixed Dyslipoproteinemias Familial combined hyperlipidemia The notion of familial combined hyperlipidemia (FCH, FCHL or multiple phenotype disease or multiple lipoprotein-type hyperlipidemia) evolved in the early 1970s from the work…
Hereditary Hypertriglyceridemias
Hereditary Hypertriglyceridemias Lipoprotein lipase deficiency (familial hyperchylomicronemia) Lipoprotein lipase (LPL) deficiency (OMIM No. 238600) is a rare autosomal recessive disorder, which was first reported as a separate entity in Europe…
Hereditary Hypercholesterolemias
Hereditary Hypercholesterolemias Introduction The ‘familial hypercholesterolemia phenotype’ has clinical and laboratory features usually ascribed to the heterozygous form of familial hypercholesterolemia (FH) (Table 1.1) secondary to a mutation of the…
Benign Hematology
Benign Hematology BIOLOGY OF HEMATOPOIESIS Anita Kumar Definition of Hematopoiesis: The formation of blood cells Sites of Hematopoiesis Bone marrow (BM) is the principal site of hematopoiesis in adults, predominantly…
Stem Cell Transplantation
Stem Cell Transplantation AUTOLOGOUS STEM CELL TRANSPLANTATION Amanda L. Olson Craig Sauter Description HDC/radiation followed by infusion of autologous multipotent hematopoietic stem cells. Tx of hematologic malignancies using HDC/radiation followed…
Leukemias and Myelodysplastic Syndromes
Leukemias and Myelodysplastic Syndromes MYELODYSPLASTIC SYNDROMES Justin M. Watts Virginia M. Klimek Epidemiology ˜10000 cases diagnosed annually in the United States Incidence >20/100000 in adults >70 y → actual incidence…
Myeloproliferative Disorders
Myeloproliferative Disorders ESSENTIAL THROMBOCYTHEMIA Raajit Rampal Clonal hematopoietic disorder resulting in ↑ red cell mass Epidemiology Incidence: Median age at dx is 60 y. 1/5 of pts under age 40…
Plasma Cell Disorders
Plasma Cell Disorders MGUS AND MULTIPLE MYELOMA (MM) Patrick W. Burke Hani Hassoun Definition Monoclonal gammopathy of undetermined significance (MGUS): Premalignancy w/clonal plasma cell (PC) proliferation. No e/o other B-cell…
