CONTROL OF THYROID-STIMULATING HORMONE SECRETION: NEURAL AND HUMORAL MODULATORS Part of “CHAPTER 15 – THYROID-STIMULATING HORMONE AND ITS DISORDERS“ NEURAL CONTROL OF THYROID-STIMULATING HORMONE SECRETION The thyrotrope secretes TSH in…
THYROID-STIMULATING HORMONE STRUCTURE, BIOSYNTHESIS, AND FUNCTION Part of “CHAPTER 15 – THYROID-STIMULATING HORMONE AND ITS DISORDERS“ GLYCOPROTEIN HORMONE STRUCTURE Thyroid-stimulating hormone (TSH, thyrotropin) is one of a family of glycoprotein…
THYROID-STIMULATING HORMONE AND ITS DISORDERS Joshua L. Cohen THYROID-STIMULATING HORMONE STRUCTURE, BIOSYNTHESIS, AND FUNCTION CONTROL OF THYROID-STIMULATING HORMONE SECRETION: NEURAL AND HUMORAL MODULATORS Related posts: DIABETES INSIPIDUS REPRESSION OF BASAL…
MANAGEMENT OF MACROPROLACTINOMAS Part of “CHAPTER 13 – PROLACTIN AND ITS DISORDERS“ Unlike patients with microprolactinomas, those with macropro-lactinomas always require therapy. Patients with macroade-nomas may have evidence of local…
CLINICAL MANIFESTATIONS OF ADRENOCORTICOTROPIN DEFICIENCY Part of “CHAPTER 14 – ADRENOCORTICOTROPIN: PHYSIOLOGY AND CLINICAL ASPECTS“ A number of pituitary pathologies can lead to ACTH deficiency, including pituitary tumor, autoimmune lymphocytic…
CLINICAL MANIFESTATIONS OF DISORDERS OF ADRENOCORTICOTROPIN EXCESS Part of “CHAPTER 14 – ADRENOCORTICOTROPIN: PHYSIOLOGY AND CLINICAL ASPECTS“ Hyperpigmentation is common when ACTH levels exceed 300 pg/mL (Fig. 14-4). The highest…
DYNAMIC TESTING OF ADRENOCORTICOTROPIN SECRETORY FUNCTION Part of “CHAPTER 14 – ADRENOCORTICOTROPIN: PHYSIOLOGY AND CLINICAL ASPECTS“ In states of possible autonomous ACTH hypersecretion, dexamethasone is used to inhibit ACTH secretion,…
FUNCTIONS OF ADRENOCORTICOTROPIN Part of “CHAPTER 14 – ADRENOCORTICOTROPIN: PHYSIOLOGY AND CLINICAL ASPECTS“ The primary action of ACTH is to promote steroidogenesis—that is, to enhance the synthesis and secretion of…
SYNTHESIS AND PROCESSING OF PROOPIOMELANOCORTIN Part of “CHAPTER 14 – ADRENOCORTICOTROPIN: PHYSIOLOGY AND CLINICAL ASPECTS“ When ACTH is synthesized in the anterior pituitary gland by the corticotropes, it is derived…
ADRENOCORTICOTROPIN: PHYSIOLOGY AND CLINICAL ASPECTS David J. Torpy Richard V. Jackson The existence of an adrenocorticotropic factor was predicted by classic pituitary ablation/pituitary extract replacement experiments.1,2 Ovine and human adrenocorticotropin…
