GONADAL EFFECTS OF GONADOTROPINS
GONADAL EFFECTS OF GONADOTROPINS Part of “CHAPTER 16 – PITUITARY GONADOTROPINS AND THEIR DISORDERS“ The only known bioeffects of LH and FSH are in the gonads. LH and FSH stimulate…
LUTEINIZING HORMONE AND FOLLICLE-STIMULATING HORMONE IN PERIPHERAL BLOOD
LUTEINIZING HORMONE AND FOLLICLE-STIMULATING HORMONE IN PERIPHERAL BLOOD Part of “CHAPTER 16 – PITUITARY GONADOTROPINS AND THEIR DISORDERS“ LH and FSH circulate in blood predominantly in the monomeric form found…
EFFECTS OF GONADAL HORMONES ON GONADOTROPINS
EFFECTS OF GONADAL HORMONES ON GONADOTROPINS Part of “CHAPTER 16 – PITUITARY GONADOTROPINS AND THEIR DISORDERS“ GONADAL STEROIDS Gonadal steroids and proteins exert direct pituitary effects on gonadotropin secretion along…
THERAPEUTIC USEFULNESS OF LUTEINIZING HORMONE–RELEASING HORMONE
THERAPEUTIC USEFULNESS OF LUTEINIZING HORMONE–RELEASING HORMONE Part of “CHAPTER 16 – PITUITARY GONADOTROPINS AND THEIR DISORDERS“ GnRH and its agonist analogs are important in the treatment of GnRH deficiency states,…
STRUCTURE, SYNTHESIS, AND STORAGE OF GONADOTROPINS
STRUCTURE, SYNTHESIS, AND STORAGE OF GONADOTROPINS Part of “CHAPTER 16 – PITUITARY GONADOTROPINS AND THEIR DISORDERS“ SUBUNIT COMPOSITION The α and β subunit structure of LH and FSH1,2 is similar…
PITUITARY GONADOTROPINS AND THEIR DISORDERS
PITUITARY GONADOTROPINS AND THEIR DISORDERS William J. Bremner Ilpo Huhtaniemi John K. Amory The gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are large glycoproteins secreted from the anterior pituitary…
CLINICAL USE OF RECOMBINANT HUMAN THYROID-STIMULATING HORMONE
CLINICAL USE OF RECOMBINANT HUMAN THYROID-STIMULATING HORMONE Part of “CHAPTER 15 – THYROID-STIMULATING HORMONE AND ITS DISORDERS“ Recombinant human TSH has been produced by cotransfecting Chinese hamster ovary cells with…
DISORDERS OF THYROID-STIMULATING HORMONE CONTROL
DISORDERS OF THYROID-STIMULATING HORMONE CONTROL Part of “CHAPTER 15 – THYROID-STIMULATING HORMONE AND ITS DISORDERS“ DISORDERS CAUSING HYPOTHYROIDISM CENTRAL HYPOTHYROIDISM Central hypothyroidism results from failure of the pituitary to secrete…
CLINICAL APPLICATIONS OF THYROID-STIMULATING HORMONE MEASUREMENT
CLINICAL APPLICATIONS OF THYROID-STIMULATING HORMONE MEASUREMENT Part of “CHAPTER 15 – THYROID-STIMULATING HORMONE AND ITS DISORDERS“ THYROID-STIMULATING HORMONE ASSAY The radioimmunoassays initially used for routine clinical measurement of TSH have…
CONTROL OF THYROID-STIMULATING HORMONE SECRETION: PHYSIOLOGIC MODULATION
CONTROL OF THYROID-STIMULATING HORMONE SECRETION: PHYSIOLOGIC MODULATION Part of “CHAPTER 15 – THYROID-STIMULATING HORMONE AND ITS DISORDERS“ EFFECTS OF AGE AND SEX TSH is first detectable in fetal serum at…
