EFFECTS OF GONADAL HORMONES ON GONADOTROPINS Part of “CHAPTER 16 – PITUITARY GONADOTROPINS AND THEIR DISORDERS“ GONADAL STEROIDS Gonadal steroids and proteins exert direct pituitary effects on gonadotropin secretion along…
THERAPEUTIC USEFULNESS OF LUTEINIZING HORMONE–RELEASING HORMONE Part of “CHAPTER 16 – PITUITARY GONADOTROPINS AND THEIR DISORDERS“ GnRH and its agonist analogs are important in the treatment of GnRH deficiency states,…
STRUCTURE, SYNTHESIS, AND STORAGE OF GONADOTROPINS Part of “CHAPTER 16 – PITUITARY GONADOTROPINS AND THEIR DISORDERS“ SUBUNIT COMPOSITION The α and β subunit structure of LH and FSH1,2 is similar…
PITUITARY GONADOTROPINS AND THEIR DISORDERS William J. Bremner Ilpo Huhtaniemi John K. Amory The gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are large glycoproteins secreted from the anterior pituitary…
CLINICAL USE OF RECOMBINANT HUMAN THYROID-STIMULATING HORMONE Part of “CHAPTER 15 – THYROID-STIMULATING HORMONE AND ITS DISORDERS“ Recombinant human TSH has been produced by cotransfecting Chinese hamster ovary cells with…
DISORDERS OF THYROID-STIMULATING HORMONE CONTROL Part of “CHAPTER 15 – THYROID-STIMULATING HORMONE AND ITS DISORDERS“ DISORDERS CAUSING HYPOTHYROIDISM CENTRAL HYPOTHYROIDISM Central hypothyroidism results from failure of the pituitary to secrete…
CLINICAL APPLICATIONS OF THYROID-STIMULATING HORMONE MEASUREMENT Part of “CHAPTER 15 – THYROID-STIMULATING HORMONE AND ITS DISORDERS“ THYROID-STIMULATING HORMONE ASSAY The radioimmunoassays initially used for routine clinical measurement of TSH have…
CONTROL OF THYROID-STIMULATING HORMONE SECRETION: PHYSIOLOGIC MODULATION Part of “CHAPTER 15 – THYROID-STIMULATING HORMONE AND ITS DISORDERS“ EFFECTS OF AGE AND SEX TSH is first detectable in fetal serum at…
CONTROL OF THYROID-STIMULATING HORMONE SECRETION: NEURAL AND HUMORAL MODULATORS Part of “CHAPTER 15 – THYROID-STIMULATING HORMONE AND ITS DISORDERS“ NEURAL CONTROL OF THYROID-STIMULATING HORMONE SECRETION The thyrotrope secretes TSH in…
THYROID-STIMULATING HORMONE STRUCTURE, BIOSYNTHESIS, AND FUNCTION Part of “CHAPTER 15 – THYROID-STIMULATING HORMONE AND ITS DISORDERS“ GLYCOPROTEIN HORMONE STRUCTURE Thyroid-stimulating hormone (TSH, thyrotropin) is one of a family of glycoprotein…
