MODEL OF THYROID-HORMONE RECEPTOR ACTION
MODEL OF THYROID-HORMONE RECEPTOR ACTION Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ On the basis of these findings, a model for the mechanism of…
TRANSCRIPTIONAL ACTIVATION BY THYROID HORMONE COACTIVATORS
TRANSCRIPTIONAL ACTIVATION BY THYROID HORMONE COACTIVATORS Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ Many factors potentially can modulate TH-mediated transcription. These include variability among…
REPRESSION OF BASAL TRANSCRIPTION/COREPRESSORS
REPRESSION OF BASAL TRANSCRIPTION/COREPRESSORS Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ Unliganded TRs bind to TREs and can repress transcription of positively regulated target…
THYROID-HORMONE RECEPTOR BINDING TO THYROID HORMONE RESPONSE ELEMENTS
THYROID-HORMONE RECEPTOR BINDING TO THYROID HORMONE RESPONSE ELEMENTS Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ TRs bind to TREs as monomers, dimers, and heterodimers…
THYROID HORMONE RESPONSE ELEMENTS
THYROID HORMONE RESPONSE ELEMENTS Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ TRs are ligand-dependent transcription factors that bind to distinct DNA sequences, generally in…
THYROID-HORMONE RECEPTORS AND THEIR STRUCTURE
THYROID-HORMONE RECEPTORS AND THEIR STRUCTURE Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ Two related TRs, which have been identified, bind TH with high affinity…
TARGET GENE REGULATION BY THYROID HORMONE
TARGET GENE REGULATION BY THYROID HORMONE Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ The effects of thyroid hormone (TH; L-thyroxine, T4; L-triiodo-thyronine, T3) on…
THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS
THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS Paul M. Yen TARGET GENE REGULATION BY THYROID HORMONE THYROID-HORMONE RECEPTORS AND THEIR STRUCTURE Related posts: REGULATION OF THE GROWTH HORMONE RECEPTOR…
REGULATION OF THYROID HORMONE ECONOMY
REGULATION OF THYROID HORMONE ECONOMY Part of “CHAPTER 30 – THYROID PHYSIOLOGY: SYNTHESIS AND RELEASE, IODINE METABOLISM, BINDING AND TRANSPORT“ Thyroid hormone regulation is directed through the neuroen-docrine–hypothalamic–pituitary–thyroid–peripheral tissue axis…
PERIPHERAL METABOLISM OF THYROID HORMONES
PERIPHERAL METABOLISM OF THYROID HORMONES Part of “CHAPTER 30 – THYROID PHYSIOLOGY: SYNTHESIS AND RELEASE, IODINE METABOLISM, BINDING AND TRANSPORT“ T4 is metabolized by the sequential removal of iodine atoms….
