Oncohema Key

REPRESSION OF BASAL TRANSCRIPTION/COREPRESSORS Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ Unliganded TRs bind to TREs and can repress transcription of positively regulated target…

THYROID HORMONE RESPONSE ELEMENTS Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ TRs are ligand-dependent transcription factors that bind to distinct DNA sequences, generally in…

THYROID-HORMONE RECEPTORS AND THEIR STRUCTURE Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ Two related TRs, which have been identified, bind TH with high affinity…

TARGET GENE REGULATION BY THYROID HORMONE Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ The effects of thyroid hormone (TH; L-thyroxine, T4; L-triiodo-thyronine, T3) on…

REGULATION OF THYROID HORMONE ECONOMY Part of “CHAPTER 30 – THYROID PHYSIOLOGY: SYNTHESIS AND RELEASE, IODINE METABOLISM, BINDING AND TRANSPORT“ Thyroid hormone regulation is directed through the neuroen-docrine–hypothalamic–pituitary–thyroid–peripheral tissue axis…

PERIPHERAL METABOLISM OF THYROID HORMONES Part of “CHAPTER 30 – THYROID PHYSIOLOGY: SYNTHESIS AND RELEASE, IODINE METABOLISM, BINDING AND TRANSPORT“ T4 is metabolized by the sequential removal of iodine atoms….

THYROID HORMONE CIRCULATION AND TRANSPORT Part of “CHAPTER 30 – THYROID PHYSIOLOGY: SYNTHESIS AND RELEASE, IODINE METABOLISM, BINDING AND TRANSPORT“ Approximately 120 nmol of T4, 47 nmol of T3, and…