Oncohema Key

CLINICAL PRESENTATION Part of “CHAPTER 65 – PAGET DISEASE OF BONE“ The localized nature of Paget disease leads to a variable clinical presentation. Frequently, only one or two bones are…

PATHOLOGY Part of “CHAPTER 65 – PAGET DISEASE OF BONE“ The initial abnormality in Paget disease is a marked increase in the rate of bone resorption at localized sites, mediated…

ETIOLOGY Part of “CHAPTER 65 – PAGET DISEASE OF BONE“ The precise etiology of Paget disease remains unknown; genetic and environmental—specifically viral—factors play a role. Geographic and ethnic epidemiologic data…

PAGET DISEASE OF BONE Ethel S. Siris Paget disease of bone is a localized disorder of skeletal remodeling in which abnormally increased rates of both bone resorption and new bone…

OTHER OSTEOLYTIC SYNDROMES Part of “CHAPTER 64 – OSTEOPOROSIS“ A number of rare syndromes can lead to some degree of bone lysis. These osteolytic syndromes can result from infectious, neoplastic,…

OTHER FORMS OF PRIMARY OSTEOPOROSIS Part of “CHAPTER 64 – OSTEOPOROSIS“ OSTEOPOROSIS IN MEN Although osteoporosis is more common in women, it is not unusual in men. One-fifth of all…

POSTMENOPAUSAL AND AGE-RELATED PRIMARY OSTEOPOROSIS Part of “CHAPTER 64 – OSTEOPOROSIS“ PATHOPHYSIOLOGY AND ETIOLOGIC CONSIDERATIONS More than 80% of osteoporosis cases occur among postmenopausal and aging populations. Although some differences…

EPIDEMIOLOGY Part of “CHAPTER 64 – OSTEOPOROSIS“ The incidence of osteoporosis increases with age. It becomes widely prevalent in the elderly, in whom it is a major public health problem,…