CORTICOTROPIN-DEPENDENT CUSHING SYNDROME Part of “CHAPTER 75 – CUSHING SYNDROME“ PITUITARY CORTICOTROPIN-DEPENDENT CUSHING SYNDROME Approximately 85% of patients with pituitary ACTH-dependent Cushing syndrome, also called Cushing disease, have pituitary microadenomas….
PATHOPHYSIOLOGY Part of “CHAPTER 75 – CUSHING SYNDROME“ Cushing syndrome can be exogenous, resulting from the administration of glucocorticoids or ACTH, or endogenous, resulting from a primary increased secretion of…
CUSHING SYNDROME David E. Schteingart Cushing syndrome is the clinical expression of the metabolic effects of persistent, inappropriate hypercortisolism. Since the disorder was first described by Harvey Cushing in 1932,…
TESTS FOR LOCALIZATION Part of “CHAPTER 74 – TESTS OF ADRENOCORTICAL FUNCTION“ Four tests are useful in localizing the site of disease in disorders of adrenal function: petrosal sinus sampling,…
TESTS FOR CONGENITAL ADRENAL HYPERPLASIA Part of “CHAPTER 74 – TESTS OF ADRENOCORTICAL FUNCTION“ Related posts: STRUVITE STONES CORTICOTROPIN-DEPENDENT CUSHING SYNDROME ANGIOTENSIN RECEPTORS PRESYNAPTIC MODULATION CONTRASEXUAL PRECOCIOUS PUBERTY IDIOPATHIC OR…
TESTS FOR ADRENAL HYPOFUNCTION Part of “CHAPTER 74 – TESTS OF ADRENOCORTICAL FUNCTION“ The normal ranges of plasma cortisol and urinary free cortisol overlap the detection limit of most assays….
TESTS FOR THE DIFFERENTIAL DIAGNOSIS OF HYPERCORTISOLISM Part of “CHAPTER 74 – TESTS OF ADRENOCORTICAL FUNCTION“ The traditional differential diagnostic tests for adrenal hyper-function, which focus on establishing the presence…
TESTS FOR DOCUMENTING HYPERCORTISOLISM Part of “CHAPTER 74 – TESTS OF ADRENOCORTICAL FUNCTION“ URINARY FREE CORTISOL Urinary free cortisol is cortisol in urine that is not conjugated to amino acids…
TESTS OF ADRENOCORTICAL FUNCTION D. Lynn Loriaux The diagnosis of adrenocortical disease depends on accurate and precise laboratory measurements. The optimal application of the available tests is an evolving process….
ACTIONS OF THE ADRENAL ANDROGENS Part of “CHAPTER 73 – CORTICOSTEROID ACTION“ Many actions of adrenal androgens are exerted through their conversion to active androgens or estrogens such as testosterone,…
