IDIOPATHIC HYPERALDOSTERONISM Part of “CHAPTER 80 – HYPERALDOSTERONISM“ CLINICAL FEATURES AND PATHOPHYSIOLOGY Idiopathic bilateral adrenocortical hyperplasia of the zona glomerulosa (idiopathic hyperaldosteronism) is characterized by features similar to those associated…
ALDOSTERONE-PRODUCING ADENOMAS Part of “CHAPTER 80 – HYPERALDOSTERONISM“ CLINICAL FEATURES AND PATHOPHYSIOLOGY Aldosterone-producing adrenocortical adenomas usually are small (0.5–2.5 cm), unilateral, solitary, and associated with hypoplastic zona glomerulosa. Occasionally, however,…
“PRIMARY ALDOSTERONISM” Part of “CHAPTER 80 – HYPERALDOSTERONISM“ Autonomous overproduction of aldosterone occurs in ˜2% of patients with hypertension and was recognized initially as being associated with either a unilateral…
PHYSIOLOGY OF ALDOSTERONE Part of “CHAPTER 80 – HYPERALDOSTERONISM“ SYNTHESIS The zona glomerulosa cells of the adrenal cortex synthesize aldosterone from corticosterone in a two-step, mixed function oxidation reaction that…
DISORDERS OF MINERALOCORTICOID EXCESS Part of “CHAPTER 80 – HYPERALDOSTERONISM“ Mineralocorticoid excess, whether primary or secondary, and disorders that mimic it are commonly manifested clinically as hypokalemia, which usually but…
HYPERALDOSTERONISM John R. Gill JR. DISORDERS OF MINERALOCORTICOID EXCESS PHYSIOLOGY OF ALDOSTERONE “PRIMARY ALDOSTERONISM” ALDOSTERONE-PRODUCING ADENOMAS Related posts: FUTURE PROSPECTS HEIGHT AND WEIGHT REGULATION OF THE GROWTH HORMONE RECEPTOR AND…
ALDOSTERONE Part of “CHAPTER 79 – RENIN-ANGIOTENSIN SYSTEM AND ALDOSTERONE“ Aldosterone is the most potent of several mineralocorticoid steroid hormones that act on the epithelium, especially in the kidney, to…
ACTIONS OF ANGIOTENSIN II Part of “CHAPTER 79 – RENIN-ANGIOTENSIN SYSTEM AND ALDOSTERONE“ Renal Sodium and Water Retention. The best known function of A-II is to support the circulation under…
ANGIOTENSIN RECEPTORS Part of “CHAPTER 79 – RENIN-ANGIOTENSIN SYSTEM AND ALDOSTERONE“ A-II binds and acts on its receptors at the cell surface. Several receptor subtypes have been found, including the…
TISSUE RENIN-ANGIOTENSIN SYSTEM Part of “CHAPTER 79 – RENIN-ANGIOTENSIN SYSTEM AND ALDOSTERONE“ Local renin-angiotensin systems in multiple tissues can produce A-II independently of the circulating renin-angiotensin system (Table 79-1). Their…
