Neuroimaging in Central Nervous System Lymphoma
Primary central nervous system lymphoma (PCNSL) is a rare aggressive high-grade type of extranodal lymphoma. PCNSL can have a variable imaging appearance and can mimic other brain disorders such as…
Neurologic and Head and Neck Manifestations of Sickle Cell Disease
Sickle cell disease is a common, inherited disordered characterized by chronic hemolytic anemia with repetitive episodes of vasoocclusion resulting from deformed red blood cells. This article reviews the most significant…
Central Nervous System Complications of Hemorrhagic and Coagulation Disorders
Hematologic disorders affect the central nervous system in a variety of ways, producing a wide range of neurologic disturbances. Early identification of these complications allows for early intervention and better…
Imaging Manifestations of Neurologic Complications in Anemia
The hallmark signs and symptoms of anemia are directly related to a decrease in oxygen delivery to vital tissues and organs and include pallor, fatigue, lightheadedness, and shortness of breath….
Neurologic Manifestations of Blood Dyscrasias
Neurologic manifestations are common in blood diseases, and they can be caused by the hematologic disorder or its treatment. This article discusses hematologic diseases in adult patients, and categorizes them…
Imaging of Neurologic Complications in Hematologic Disorders
Sangam Kanekar, MD, Editor Hematologic disorders often affect the central and peripheral nervous systems in a number of different ways, producing a wide range of neurologic symptoms. Some of these…
Use of Direct Oral Anticoagulants in Special Populations
Direct oral anticoagulants (DOACs) have been approved for the treatment of venous thromboembolism and atrial fibrillation based on randomized controlled trials (RCTs) of direct comparisons with vitamin K antagonists. Despite…
Regulatory Impact on Thrombosis Treatment, Prevention, and Anticoagulant Use
Thromboembolism afflicts millions of patients annually in the United States and is associated with a significant cost burden. Oral anticoagulants provide clinicians with options for management of these diseases and…
The Intrinsic Pathway of Coagulation as a Target for Antithrombotic Therapy
Plasma coagulation in the activated partial thromboplastin time assay is initiated by sequential activation of coagulation factors XII, XI, and IX. While this series of proteolytic reactions is not an…
Reversal Agents for the Direct Oral Anticoagulants
The vitamin K antagonists (VKAs) are associated with a significant rate of major and fatal bleeding complications. The new direct oral anticoagulants (DOACs), even though having a better bleeding profile…
