Langerhans cell histiocytosis (LCH) is a disease caused by clonal proliferation of CD1a+/CD207+ cells that is characterized by a spectrum of varying degrees of organ involvement and dysfunction. Treatment of LCH…
The discovery of recurrent somatic genomic alterations in Langerhans cell histiocytosis (LCH) has led to a new understanding of LCH as a clonal neoplastic disorder. Most of the abnormalities described…
Langerhans cell histiocytosis (LCH) is heterogeneous disease characterized by common histology of inflammatory lesions containing Langerin + (CD207) histiocytes. Emerging data support a model in which MAPK activation in self-renewing…
The classification of the histiocytoses has evolved based on new understanding of the cell of origin as a bone marrow precursor. Although the pathologic features of the histiocytoses have not…
Nancy Berliner, MD, Editor Barrett J. Rollins, MD, PhD, Editor Histiocytes are bone marrow–derived cells that protect the body from foreign substances by phagocytosing them and, in some cases, using…
Overexpression of epidermal growth factor receptor (EGFR) is linked with poor prognosis in squamous cell carcinoma of the head and neck (SCCHN). Cetuximab binds specifically to EGFR with high affinity;…
Supportive care and survivorship strategies in the management of head and neck squamous cell carcinoma (HNSCC) revolve around continued collaborative efforts aimed at early identification and intervention for locoregional disease…
Salivary gland malignant tumors represent a diverse group of neoplasms. Their low incidence makes research studies challenging, with most therapeutic recommendations based on case reviews, single-arm trials, or small randomized…
Surgery remains the most important effective treatment for differentiated (DTC) and medullary thyroid cancer (MTC). Radioactive iodine (RAI) is another important treatment but is reserved only for DTC whose disease…
Radiotherapy is the primary treatment of nasopharyngeal carcinoma and combination chemotherapy can enhance treatment outcomes for locoregionally advanced disease. The Intergroup 0099 study using concurrent-adjuvant cisplatin-based chemoradiotherapy was the first…
