Hemolysis from ABO Incompatibility
ABO incompatibility of red blood cells leads to brisk complement-mediated lysis, particularly in the setting of red cell transfusion. The ABO blood group is the most clinically significant blood group…
Complement
The complement system is an essential component of the immune system. It is a highly integrative system and has a number of functions, including host defense, removal of injured cells…
Complement in Health and Disease
Robert A. Brodsky, MD, Editor Related posts: Complement in Health and Disease Ultralarge Von Willebrand Factor–Induced Platelet Clumping and Activation of the Alternative Complement Pathway in Thrombotic Thrombocytopenic Purpura and…
Novel Therapeutics for Pancreatic Adenocarcinoma
The last decade has seen significant developments in the use of combination systemic therapy for advanced pancreatic ductal adenocarcinoma (PDAC), with median survival approaching 1 year for select patients treated with…
Therapeutic Approaches for Metastatic Pancreatic Adenocarcinoma
Since the US Food and Drug Administration’s approval of gemcitabine in 1996, numerous randomized trials have investigated treatment programs to further improve the quality of life and survival of patients…
Treatment Approaches to Locally Advanced Pancreatic Adenocarcinoma
This article focuses on the management of locally advanced pancreatic cancer, which should be treated as a distinct entity separate from metastatic disease and borderline resectable disease. Although the role,…
Diagnosis and Management of Borderline Resectable Pancreatic Adenocarcinoma
Borderline resectable pancreatic cancer represents a subcategory of advanced cancer that is typically defined by limited involvement of the major mesenteric vasculature. Such involvement is associated with a high likelihood…
Perioperative Therapy for Surgically Resectable Pancreatic Adenocarcinoma
It is estimated that 10% to 20% of patients with pancreatic cancer present with resectable disease. Although surgery offers curative intent, the median survival after curative resection is less than…
Surgery for Pancreatic Cancer
Surgical resection remains the only potentially curative therapy for pancreatic cancer, despite a high rate of systemic recurrence. Because of local invasion or distant spread, a minority of patients presenting…
Diagnosis and Management of Pancreatic Cystic Neoplasms
Incidentally discovered pancreatic cystic lesions are increasingly common, affecting up to 10% to 15% of patients undergoing cross-sectional imaging. Although some pancreatic cystic neoplasms harbor invasive malignancy or the potential…
