Hematologic Malignancies
Hematologic Malignancies Utkarsh H. Acharya, DO, FACP Tejaswini Dhawale, MD James S. Blachly, MD Johnnie J. Orozco, MD, PhD Keri Maher, DO Clifton Mo, MD David Bond, MD A 40-year-old…
Palliative Care, Survivorship, and Communication
Palliative Care, Survivorship, and Communication Olga Kozyreva, MD Keith Eaton, MD, PhD A 56-year-old woman with borderline resectable pancreatic cancer is admitted for severe mucositis following cycle 2 of neoadjuvant…
Cancer Biology and Hereditary Cancer Syndromes
Cancer Biology and Hereditary Cancer Syndromes Utkarsh H. Acharya, DO, FACP Tejaswini Dhawale, MD Mutations of the CDH1 gene have been associated with which condition? View Answer Hereditary diffuse gastric…
Clinical Pharmacology and Cancer Therapeutics
Clinical Pharmacology and Cancer Therapeutics Utkarsh H. Acharya, DO, FACP Tejaswini Dhawale, MD A patient with stage III colorectal cancer is placed on adjuvant capecitabine and oxaliplatin with a creatinine…
Primary Aldosteronism in Pregnancy
Primary aldosteronism (PA) is uncommon in pregnancy, with fewer than 64 cases reported in the medical literature; most of these reported patients had aldosterone-producing adenomas (APAs). PA can lead to…
The Peripartum Diagnosis of Pheochromocytoma and a Genetic Mystery Solved
As we have highlighted in the other cases, the clinical management of catecholamine-secreting pheochromocytomas or paragangliomas (PPGLs) can be very challenging—both diagnostically and therapeutically. However, when PPGL is diagnosed in…
Catecholamine-Secreting Paraganglioma in Pregnancy
As we have highlighted in the other cases, the clinical management of catecholamine-secreting pheochromocytomas or paragangliomas (PPGLs) can be challenging—both diagnostically and therapeutically. However, when PPGL is diagnosed in the…
Pregnancy in a Patient With 21-Hydroxylase Deficiency
The most common type of congenital adrenal hyperplasia (CAH) is 21-hydroxylase deficiency, which occurs in 1 in 10,000 live births. The goals of therapy in CAH include (1) replacement therapy…
Sorting Out the Source of Androgen Excess in a Postmenopausal Woman With an Adrenal Mass
Postmenopausal androgen hypersecretion may be due to an ovarian tumor, an adrenal tumor, or ovarian hyperthecosis. It is important to assess the patient with a full androgen profile and imaging…
Malignant Pheochromocytoma in Pregnancy
As we have highlighted in the other cases, the clinical management of catecholamine-secreting pheochromocytomas or paragangliomas (PPGLs) can be challenging—both diagnostically and therapeutically. However, when PPGL is diagnosed in the…
