Molecular Markers for Incidence, Prognosis, and Response to Therapy
Lung cancer is the most common malignancy in the United States and worldwide. In 2011, it is estimated that more than 221,000 people in the United States will be diagnosed…
Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection, and Beyond: Full-Layer Resection for Gastric Cancer with Nonexposure Technique (CLEAN-NET)
Mucosal cancer in the gastrointestinal tract generally has low risk of lymph node metastasis. Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are techniques of local excision of neoplasia…
Phase I and II Clinical Trials for Gastric Cancer
Gastric cancer remains a global public health problem with considerable heterogeneity in pathogenesis and clinical presentation across geographic regions. Improved understanding of the molecular biology of this disease has opened…
Preoperative and Postoperative Chemotherapy for Gastric Cancer
Radical surgery offers the only chance of cure for patients with operable gastric cancer; however, outcomes remain generally poor due to a high rate of relapse post gastric surgery. Multimodality…
Surgery for Gastric Cancer: What the Trials Indicate
To optimize the therapeutic value of an operation for cancer, surgeons must weigh survival value against mortality/morbidity risk. As a result of several prospective, randomized trials, many surgeons feel that…
Gastric Cancer Eastern Experience
Several guidelines are used for cancer therapy throughout the world. The Japan Gastric Cancer Association guideline, whereby standard surgery for T2 to T4 curable gastric cancer is defined as more…
Gastric Cancer: Endoscopic Diagnosis and Staging
Gastric cancer is common and is a cause of severe morbidity and mortality. Early diagnosis can improve the chances of cure and prolong survival because prognosis is inversely related to…
Familial Gastric Cancer: Genetics, Diagnosis, and Management
This article focuses on the diagnosis and management of familial gastric cancer, particularly hereditary diffuse gastric cancer (HDGC). First, existing consensus guidelines are discussed and then the pathology and genetics…
Gastrointestinal Stromal Tumors of the Stomach
Gastrointestinal stromal tumors (GISTs) are relatively rare mesenchymal tumors located within the submucosa of the GI tract. The defining characteristic of GISTs is the presence of the cell-surface antigen CD117…
Standard D2 and Modified Nodal Dissection for Gastric Adenocarcinoma
The quality of surgical treatment is a major determinant of cancer treatment outcomes; however, controlling surgical quality is a difficult task. Surgical treatment of gastric cancers, and especially the benefits…
