Unusual Breast Histologies
BACKGROUND Print Section Listen As our understanding of the biology of breast cancer evolves, we recognize that there are many different types of histologically distinct cancers. Breast cancer is ahead…
Breast Cancer Subtypes Identified by Gene Expression Profiles and Molecular Markers
INTRODUCTION Print Section Listen In 2000, the era of genomic medicine in breast cancer was introduced when Perou et al1 identified the “molecular portraits” of breast cancer. By analyzing the…
Overview of Systemic Therapy
INTRODUCTION Print Section Listen Breast cancer is the most common cancer in women and it is estimated that one in eight women in the United States will develop breast cancer…
Management of the Clinically Negative Axilla in Patients with Invasive Breast Cancer
INTRODUCTION Print Section Listen Appropriate axillary staging is a critical component of breast cancer care. In addition to being an important prognostic factor, nodal status and the extent of nodal…
Genetic and Familial Syndromes
INTRODUCTION Print Section Listen Genetic predisposition accounts for only a fraction of breast cancers, but genetic testing, in the appropriate context, is the most powerful tool available for quantitative risk…
Ductal Carcinoma in Situ
INTRODUCTION Print Section Listen Ductal carcinoma in situ (DCIS) is a preinvasive clinical diagnosis that lies in the continuum between epithelial atypia and invasive cancer. Although it has been recognized…
Survivorship Issues in Breast Cancer
INTRODUCTION Print Section Listen Improvements in diagnosis and advances in targeted therapies have contributed to the increasing numbers of breast cancer survivors. The most recent estimate by the Surveillance Epidemiology…
Mastectomy and Breast Reconstruction
HISTORICAL PERSPECTIVE Print Section Listen Mastectomy has been utilized in the surgical management of patients with breast cancer for centuries. It was William Stewart Halsted who popularized the technique of…
Screening for Breast Cancer
INTRODUCTION Print Section Listen Breast cancer remains the most common cancer in American women, excluding cancers of the skin, and accounts for 29% of all female cancer in the United…
Lobular Carcinoma in Situ and Lobular Neoplasia
BACKGROUND Print Section Listen The term lobular neoplasia (LN) encompasses the entire spectrum of atypical epithelial lesions that originate in the terminal duct-lobular unit (TDLU) of the breast, and are…
