Lentivector Vaccines
Keywords Lentiviral vector, lentivector, cancer vaccine, gene therapy, immunotherapy, cancer Introduction The immune system likely evolved to fight off disease caused by infections with foreign pathogens. However, it has…
RNA Interference Therapeutics for Tumor Therapy: Promising Work in Progress
Keywords RNA interference (RNAi), short hairpin RNA (shRNA), ABCD nanoparticle, convection-enhanced delivery (CED), O 6 -methylguanine–DNA methyltransferase (MGMT), malignant glioma, temozolomide (TMZ), genetically modified T cell therapy Introduction Gene…
Poxvirus-Based Strategies for Combined Vaccine and Tumor Microenvironment Manipulation
Keywords Tumor microenvironment, poxvirus, immunotherapy, immune escape Introduction The underlying hypothesis/strategy of our approach to immunotherapy is that by modulating the tumor microenvironment, we will be able to induce…
Clinical Application of Plasmid-Based Cancer Vaccines
Keywords Cancer clinical trials, DNA, plasmid, vaccine Introduction Vaccination ranks among mankind’s greatest medical achievements. Routine immunization has eradicated small pox; virtually stamped out polio; and reduced the worldwide…
Genetically Engineered (T Cell Receptor) T Cells for Adoptive Therapy
Keywords T cell receptor, chimeric antigen receptor, cancer, adoptive immunotherapy, gene therapy Introduction There are two types of immune responses: humoral immunity and cellular immunity. Humoral immunity is mediated…
Chemokine Gene-Modified Dendritic Cells for Cancer Therapy
Keywords Chemokines, antitumor immunity, immunotherapy, dendritic cells, tumor-infiltrating T cells Introduction Dendritic cells (DCs) are highly specialized, professional antigen-presenting cells (APCs) that activate naive T cells and are being…
Reoviral Therapy for Cancer: Strategies for Improving Antitumor Efficacy Using Radio- and Chemotherapy
Keywords Reovirus, chemotherapeutics, radiotherapy, cancer, clinical trials Introduction The use of viruses in the treatment of cancer resulted from the observation that clinical remission was occasionally seen in patients…
Toxin-Based Cancer Gene Therapy: Under the Control of Oncofetal H19 Regulatory Sequences
Keywords DTA-H19 plasmid, H19, oncofetal, cancer, transcriptional targeting, diphtheria toxin, tumor-specific promoter, hypoxia Introduction Reviewing brochures on the conventional cancer drugs in use today is undoubtedly a horrible and…
Genetically Modified Dendritic Cell Vaccines for Solid Tumors
Keywords Cancer cells, Immune system, Dendritic cells, Genetically modified dendritic cell vaccination, Tumor antigens, Melanoma Introduction The immune system has the potential to control or eliminate cancer cells. This…
Selectively Replicating Herpes Simplex Viral Vectors
Keywords HSV, oncolysis, immune response, therapeutic transgene, safety, vector delivery, glioma Introduction Herpes simplex virus 1 (HSV-1) is a large, naturally neurotropic, double-stranded DNA virus. Primary infection with wild-type…
