Keywords Oncolytic virotherapy, brain tumors, gliomas, adenoviruses, autophagy, therapy, cancer Introduction Oncolytic virotherapy utilizes the ability of replicating viruses to selectively infect malignant cells, replicate within them, and subsequently…
Keywords Electroporation, gene therapy, cancer, nucleic acids, vaccine Introduction Electroporation or electropermeabilization (EP) is a physical method of introducing polar molecules such as DNA into eukaryotic cells through the…
Keywords Suicide gene, GDEPT, cancer therapy, enzyme prodrug, thymidine kinase, nitroreductase, cytosine deaminase, carboxypeptidase G2, cytochrome P450, bystander effect Introduction Cancer chemotherapy has had an evolutionary history since the…
Keywords Transkingdom RNAi (tkRNAi), bacteria-mediated RNAi (bmRNAi), RNA-based therapeutics, RNA interference (RNAi), Cancer, Bacteria Introduction During approximately the past three decades, researchers have been searching for new and improved…
Keywords Viral insertion sites, gene therapy, insertional mutagenesis, lentivial vectors, retroviral vectors, provirus, P140K MGMT Introduction: Why we Should Know Viral Insertion Sites Cancer gene therapy is an emerging…
Keywords Targeted anti-angiogenic gene therapy, nonviral vector, viral vector, tumor-specific promoter, antibody conjugation, peptide conjugation, adeno-associated virus phage, tumor necrosis factor-α Introduction The microenvironment in which a tumor originates…
Keywords Adoptive immunotherapy, dendritic cells, electropermeabilization, gene delivery systems, gene editing, gene silencing, gene transfer, hematopoietic, lentiviral vectors, LTR, mesenchymal stem cells, mitochondrion gene therapy, pseudotyping, retroviral vectors, RNAi, RRE,…
Keywords Cancer, vaccines, poxviruses, TRICOM, immunotherapy, intratumoral vaccination, immunostimulatory molecules, costimulatory molecules In this chapter, we review the use of recombinant poxviral vectors containing transgenes for costimulatory molecules and…
Keywords FDA, CBER, cancer gene therapy, regulatory review, CMC, pharmacology/toxicology, clinical, drug development Introduction FDA’s Regulatory Responsibility and Gene Therapy Submissions In the United States, the U.S. Food and…
Keywords MGMT, P140K, chemoprotection, drug-resistance gene therapy, hematopoietic stem cell gene therapy, glioblastoma Introduction to MGMT Gene Transfer in Cancer Therapeutics The O 6 -methylguanine methyltransferase (MGMT) catalytic protein…
