The efficacy of adjuvant mitotane therapy and radiotherapy following adrenalectomy in patients with adrenocortical carcinoma: A systematic review and meta-analysis

May 11, 2025 by in ONCOLOGY Comments Off on The efficacy of adjuvant mitotane therapy and radiotherapy following adrenalectomy in patients with adrenocortical carcinoma: A systematic review and meta-analysis

Highlights • This is the first systematic review and meta-analysis, including randomized controlled trials, to investigate the oncological outcomes of adjuvant therapy after radical adrenalectomy in patients with adrenocortical carcinoma….

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“I was in a very deep, dark place… I wasn’t prepared for that”: A qualitative assessment of the emotional well-being needs of patients undergoing cystectomy

May 11, 2025 by in ONCOLOGY Comments Off on “I was in a very deep, dark place… I wasn’t prepared for that”: A qualitative assessment of the emotional well-being needs of patients undergoing cystectomy

Highlights • Patients undergoing cystectomy have significant emotional and mental health needs. • Providers should proactively address the mental health needs of these patients. • Mental health specialists should be…

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Development of TAR-200: A novel targeted releasing system designed to provide sustained delivery of gemcitabine for patients with bladder cancer

May 11, 2025 by in ONCOLOGY Comments Off on Development of TAR-200: A novel targeted releasing system designed to provide sustained delivery of gemcitabine for patients with bladder cancer

Highlights • Development of novel therapies is needed for patients with high-risk bladder cancer. • TAR-200 is a gemcitabine intravesical releasing system designed for bladder cancer. • TAR-200 was well…

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Is primary retroperitoneal lymph node dissection the way forward for patients with testicular seminoma and limited retroperitoneal metastases?

May 11, 2025 by in ONCOLOGY Comments Off on Is primary retroperitoneal lymph node dissection the way forward for patients with testicular seminoma and limited retroperitoneal metastases?

Highlights • Testicular cancer makes up 1% of adult tumors and is the most common in young men. • CS II seminoma management options include radiotherapy, chemotherapy, or RPLND. •…

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Oncologic outcomes of pelvic organ-preserving radical cystectomy vs. Standard radical cystectomy: A systematic review and meta-analysis

May 11, 2025 by in ONCOLOGY Comments Off on Oncologic outcomes of pelvic organ-preserving radical cystectomy vs. Standard radical cystectomy: A systematic review and meta-analysis

Highlights • Overall Survival (OS): Five studies with 272 POPRC and 324 SRC patients showed no significant difference in OS between procedures (HR 1.02; P = 0.87). No difference was noted…

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Graves’ Hyperthyroidism in Pregnancy

Nov 10, 2024 by in ENDOCRINOLOGY Comments Off on Graves’ Hyperthyroidism in Pregnancy

Background Graves’ hyperthyroidism (GH) in pregnancy affects less than 0.5% of pregnant women. Prior to the advent of antithyroid drugs (ATDs) in the 1940s, GH perinatal mortality was as high…

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