Molecular Genetics of MEN1-Related Neuroendocrine Tumors
Fig. 3.1 MEN1 gene and missense mutations. (a) Genomic structure of the MEN1 gene. The 10 exons of the gene are shown as boxes that are sized with the indicated…
Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors
Fig. 20.1 Distribution of neuroendocrine tumors Except for the undisputed role of surgery in the management of neuroendocrine tumors, the development and registration of the somatostatin analogs (congeners) octreotide and…
Molecular Genetics of Pheochromocytoma and Paraganglioma
Fig. 2.1 Representation of all reported pheochromocytoma/paraganglioma susceptibility genes, specifying the year of publication, with special attention to the genes involved in the hereditary predisposition to the disease (opaque colored…
Tumor Metabolism and Metabolomics of Pheochromocytomas and Paragangliomas
Fig. 11.1 Krebs cycle gene mutations in pheochromocytoma and paraganglioma and their downstream cellular effects. Mutations in succinate dehydrogenase (SDH) subunit and assembly factor genes, fumarate hydratase (FH), and mitochondrial…
Alpha Radionuclide Therapy: Principles and Applications to NETs
Radionuclide T1/2 (h) Emission Energy deposited (MeV maximum)a Source Ra-223 273.6 4 Alpha 2 Beta 4 Gamma 2 X-ray Alpha 5.6, 6.8, 7.4, (6.6 or 7.50) Beta 0.48, 0.50 Gamma,…
131I-Meta-Iodobenzylguanidine Therapy for Pheochromocytoma/Paraganglioma and Neuroblastoma
Fig. 19.1 Structural similarities of adrenaline (upper molecule), noradrenaline (middle molecule), and 131I-mIBG (lower molecule) 19.1.2 mIBG: Uptake Mechanism Meta-iodobenzylguanidine moves into cells by the mechanism of noradrenaline reuptake of…
Molecular Genetics of Neuroblastoma
Fig. 5.1 Landscape of genetic variation in high-risk neuroblastoma (Nature Genetics 2013). MYCN amplification, deletion of chromosomes 1p, 3p, and 11q, gain of chromosomes 1q, 2p, and 17q, as well…
Molecular Genetics of Gastroenteropancreatic Neuroendocrine Tumours
© Springer International Publishing Switzerland 2017Karel Pacak and David Taïeb (eds.)Diagnostic and Therapeutic Nuclear Medicine for Neuroendocrine TumorsContemporary Endocrinology10.1007/978-3-319-46038-3_6 6. Molecular Genetics of Gastroenteropancreatic Neuroendocrine Tumours Samuel Backman1 and Peyman Björklund1 (1) Experimental Surgery, Department of Surgical…
Bridging Between Experiments and Equations: A Tutorial on Modeling Excitability
Chapter 1Bridging Between Experiments and Equations: A Tutorial on Modeling Excitability David P. McCobb1 and Mary Lou Zeeman2 1Department of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA 2Department of…
Endoplasmic Reticulum- and Plasma-Membrane-Driven Calcium Oscillations
Chapter 3Endoplasmic Reticulum- and Plasma-Membrane-Driven Calcium Oscillations Arthur Sherman Laboratory of Biological Modeling, NIDDK, National Institutes of Health, USA 3.1 Introduction Calcium () is of great importance throughout biology because…
