Fig. 3.1 Generation and inflammatory cellular targets of extracellular heme in sickle cell disease. Hemolysis releases cell-free hemoglobin (Hb), which is normally scavenged by haptoglobin and CD163. Free hemoglobin reacts…
Fig. 1.1 Diagram of the human airway system . There are 23 generations of branching airways on average, beginning with larger airways in the conducting zone, consisting of the trachea…
Mechanisms of TRALI Two pathophysiologic mechanisms of TRALI have been recognized, immune-mediated TRALI and non-antibody mediated TRALI. Anywhere from 65 to 90 % of reported cases are found to be…
VWF:Ag VWF:RCo VWF:RCo/VWF:Ag FVIIII Multimer pattern LD-RIPA Platelet count Other specialized testing Type 1 Mild decrease Mild decrease >0.5–0.7 Normal or mild decrease Normal Absent Normal Type 1C Mild…
Figs. 13.1 and 13.2 Antiphospholipid antibody-associated skin ulcers Expert Opinion 1 (Paulo Ricardo Criado, Dermatology) Livedoid vasculopathy is a recurrent painful ulcerative disorder, on the skin of the lower extremities,…
Infectious agent APS manifestations Staphylococcus aureus CAPS [142] Streptococcus pyogenes Cardiac valve and CNS lesions [133, 137] Escherichia coli CAPS [143] Klebsiella CAPS [144] Hepatitis C Thrombosis, brain infarction [145]…
Fig. 6.1 Blocking the actions of antiphospholipid antibodies (aPL). (A) The monoclonal antibody, N11, prevents the actions of aPL on trophoblast and endothelial cells and attenuates aPL-associated pregnancy complications and…
Model (order determined by date of first published report) Notes on pathophysiology Protective interventions Femoral vein pinch injury (mouse): injection of patient aPL, followed by a standard pinch injury to…
Clinical criteria 1. Vascular thrombosis One or more clinical episodes of arterial, venous, or small vessel thrombosis, in any tissue or organ. Thrombosis must be confirmed by objective validated criteria…
© Springer International Publishing AG 2017Doruk Erkan and Michael D. Lockshin (eds.)Antiphospholipid Syndrome10.1007/978-3-319-55442-6_18 18. 15th International Congress on Antiphospholipid Antibodies Task Force on Antiphospholipid Syndrome Treatment Trends Report Danieli Andrade1 , Ricard Cervera10, Hannah Cohen11, Mark Crowther12, Maria J. Cuadrado13, Guillaume Canaud14, David A. Garcia15,…
