and Image Guided Systemic Radiotherapy
Fig. 1 Select examples of radiation dose-toxicity curves demonstrating that a reduction in dose to normal organs is associated with a decrease in late organ toxicities such as pneumonitis, nephritis and…
Modeling in Radiation Oncology
where α (1/Gy) and β (1/Gy2) are parameters that determine the shape of the curve. Indeed, a vast literature exists on the mechanistic and empirical history of this famous equation,…
Applications of Magnetic Resonance Guided Focused Ultrasound
Fig. 1 Schematic of a FUS procedure, a method of focusing sound waves to create heat at a focal spot at depth in the body. The tissue temperature at the focal…
Stem Cells and Tumor Microenvironment in Radiotherapy
Fig. 1 Representative images showing the different acini structures generated from immortalized normal human breast epithelial MCF10A, breast cancer MCF7 and BCSCs isolated from MCF7 population that survived a course of…
and Hypofractionation for Primary Tumors
Fig. 1 External compression was one of the first techniques used to address tumor motion in lung SBRT Fig. 2 Image guidance with CBCT prior to delivery was sufficient to provide treatment…
Mammalian DNA Damage Response as a Target for Therapeutic Gain in Radiation Oncology
© Springer International Publishing AG 2017Jeffrey Y.C. Wong, Timothy E. Schultheiss and Eric H. Radany (eds.)Advances in Radiation OncologyCancer Treatment and Research10.1007/978-3-319-53235-6_11 The Mammalian DNA Damage Response as a Target for Therapeutic Gain in Radiation…
and Radiotherapy
© Springer International Publishing AG 2017Jeffrey Y.C. Wong, Timothy E. Schultheiss and Eric H. Radany (eds.)Advances in Radiation OncologyCancer Treatment and Research10.1007/978-3-319-53235-6_10 Biomarkers and Radiotherapy Savita V. Dandapani1 (1) Department of Radiation Oncology, City of Hope, Duarte,…
and the Treatment of Oligometastatic Disease
Publication Year Number of patients Median follow-up (months) RT dose Metastases control Overall survival University of Chicago (Wong et al. 2016) 2016 61 82 24–48 Gy in 3 fractions 44% at…
Impact of IGRT on Normal Tissue Toxicity
. where P(D, 1) is the probability of a lesion occurring if the entire organ is irradiated to dose D. This formula was derived using the simple notion that the…
Radiotherapy and Immunotherapy
Fig. 1 Ideally, drug combinations should shift the balance between the pro-immunogenic and immunosuppressive effects of radiotherapy to favor its pro-immunogenic effects and or abrogate the immune-suppressive ones. Multiple strategies in…
