Herpes Simplex Virus Infections
Chapter 48 Herpes Simplex Virus Infections Kimberly Y. Smith, MD, MPH, Harold A. Kessler, MD PATHOGEN Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are common pathogens in…
Coccidioidomycosis
Chapter 45 Coccidioidomycosis Neil M. Ampel, MD INTRODUCTION Coccidioidomycosis is an infection caused by the dimorphic fungus Coccidioides. The endemic region for this mycosis is confined to the Western hemisphere…
Saquinavir
Chapter 15 Saquinavir Anton Posniak, MD, FRCP, Kasha P. Singh, MBBS, FRACP INTRODUCTION On the 4 December 1997, the Society for Medicines Research Award for Drug Discovery was presented to…
Drug Interactions and Administration
Chapter 79 Drug Interactions and Administration Charles Flexner, MD, Paul A. Pham, PharmD Pharmacology plays a critical role in the treatment of HIV infection affecting issues as diverse as adherence,…
Abnormalities of Fat Distribution in HIV Infection
Chapter 73 Abnormalities of Fat Distribution in HIV Infection Carl Grunfeld, MD, PhD Shortly after the introduction of combination antiretroviral therapy with HIV protease inhibitors (PIs), changes in fat (Table…
Enfuvirtide
Chapter 23 Enfuvirtide J. Michael Kilby, MD Prior to the accelerated FDA approval in 2003 of the membrane fusion inhibitor, enfuvirtide (ENF), all available antiretroviral agents were directed against one…
General Immune-Based Therapies in the Management of HIV-Infected Patients
Chapter 30 General Immune-Based Therapies in the Management of HIV-Infected Patients Irini Sereti, MD, Joseph A. Kovacs, MD The development of highly active antiretroviral drugs, especially protease inhibitors (PIs) or…
Diseases of the Esophagus, Stomach, and Bowel
Chapter 77 Diseases of the Esophagus, Stomach, and Bowel C. Mel Wilcox, MD The early years of the acquired immunodeficiency syndrome (AIDS) epidemic highlighted the gastrointestinal (GI) tract as a…
Mycobacterium Avium Complex and Other Atypical Mycobacterial Infections
Chapter 41 Mycobacterium Avium Complex and Other Atypical Mycobacterial Infections Constance A. Benson, MD, Judith S. Currier, MD CLINICAL SYNDROMES Mycobacterium avium complex (MAC) disease in patients with human immunodeficiency…
Microsporidiosis
Chapter 39 Microsporidiosis Louis M. Weiss, MD, MPH Microsporidia is a nontaxonomic designation used to refer to a group of obligate, intracellular parasites belonging to the phylum Microsporidia.1,2 The Microsporidia…
