Febrile Neutropenia
Clinical scenario Recommendation Level of evidencea Risk stratification Must be individualized at local institutions due to lack of evidence to support the needs of each individual treatment area 2C Baseline…
Knowledge Gaps and Opportunities for Research
© Springer Berlin Heidelberg 2015James H. Feusner, Caroline A. Hastings and Anurag K. Agrawal (eds.)Supportive Care in Pediatric OncologyPediatric Oncology10.1007/978-3-662-44317-0_18 18. Knowledge Gaps and Opportunities for Research Anurag K. Agrawal1 , Caroline A. Hastings1 and James H. Feusner1 (1) Department of Hematology/Oncology, Children’s…
Immunization Practice in Pediatric Oncology
Prior to chemotherapyb During chemotherapyc After chemotherapy completionc, d Diphtheria-tetanus-acellular pertussis Continuation of primary series during lower-intensity phases of therapy (i.e., ALL in maintenance) Continuation of primary series; booster…
Hematopoietic Growth Factors
Clinical scenario Recommendation Level of evidenceb Treatment of myelosuppression after chemotherapy (primary prophylaxis) Consider if risk of neutropenia is ≥20 % or if patient had neutropenia with previous course of…
Prevention of Infection
Recommendation Grade Comments Reference Data from studies of non-oncology patientsa Data from studies of adult oncology patientsa Data from studies of pediatric oncology patientsa Antibacterial prophylaxis with a fluoroquinolone should…
Cardiopulmonary Emergencies
Clinical scenario Recommendations Level of evidencea SVCS/SMS Elevate head of the bed 1C Place all IV lines in lower extremities 2C Consider use of loop diuretics 2C Remove indwelling catheter…
The Acute Abdomen
Treatment modality Potential side effects Chemotherapy Bacterial overgrowth Bile acid malabsorption Pancreatic insufficiency Neutropenic enterocolitis Edema, ulceration, atrophy Increased bowel permeability Transmural infection Radiation therapy Radiation enteritis Stricture Inflammation/cell death…
Management of Acute Radiation Side Effects
Organ RT side effect Treatment Level of evidenceb Hematologic Neutropenia Consider G-CSF (see Chap. 15 for more detail) 1C Thrombocytopenia Platelet transfusion 1C Anemia Red blood cell transfusion; erythropoietin (EPO)-stimulating…
Nausea and Vomiting
High risk (>90 % frequency of emesis in the absence of prophylaxis) Altretamine bCytarabine 3 g/m2/dose Procarbazine (oral) bCarboplatin Dacarbazine Streptozocin Carmustine >250 mg/m2 bDactinomycin bThiotepa ≥300 mg/m2 bCisplatin Mechlorethamine bCyclophosphamide…
