Fig. 1 Cross talk of the epigenetic alterations in cancer. The three classes of epigenetic modifications, such as DNA methylation, histone modifications, and noncoding RNA-based mechanisms, cause changes in the…
Cell line Reported IC50 (μM) Concentration (in μg/mL) Citations Cervical HeLa 80 24.18 Priyadarsini et al. (2011) Breast MCF-7 92.4 27.93 Chou et al. (2010) Prostate PC-3 100 30.22 Senthilkumar…
Fig. 1 Mechanisms of MDR towards cancer chemotherapeutic drugs. Cancer cells can develop resistance to multiple drugs by various mechanisms as depicted. Mechanisms include (a) decreased uptake of drug, (b)…
Fig. 1 The KD alters overall gene expression to more closely resemble that seen in normal brain. Total cellular RNA was isolated from the tumor and the non-tumor containing contralateral…
Fig. 1 Figure shows a timeline of the various periods (over the last 3000–4000 years) of Black seed use that has led to the discovery of Thymoquinone. The first description…
Fig. 1 Schematic overview of CXCR4-SDF-1α-induced intracellular signal transduction pathway and desensitization of activated receptor signaling Since SDF-1α is constitutively expressed, it has been reported that shutting off continuous stimulation…
Trial numbera Objectives Patient population Intervention Stage of trial Country NCT01473290 Prevention of gastrointestinal complication Cancer patients treated by chemotherapy or radiation therapy to pelvic region VSL#3 (mixture of probiotic…
Ahern TP, Pedersen L, Tarp M et al (2011) Statin prescriptions and breast cancer recurrence risk: a Danish nationwide prospective cohort study. J Natl Cancer Inst 103:1461–1468 Alexander DD, Morimoto…
Fig. 1 Molecular targets of genistein on cancer cells. Genistein exhibits either stimulatory or inhibitory effects on different signaling pathways. Abbreviations: COX-2 cyclooxygenase-2, FAK focal adhesion kinase, HIF-1α hypoxia-inducible factor…
Ahmed RL, Schmitz KH, Anderson KE, Rosamond WD, Folsom AR (2006) The metabolic syndrome and risk of incident colorectal cancer. Cancer 107:28–36 Alberti KGMM, Zimmet P, Shaw J (2006) Metabolic…
