Oncohema Key

Fig. 9.1 Signaling by ErbB homodimers in comparison with ErbB2-containing heterodimers. Receptors are shown as two lobes connected by a transmembrane stretch. Binding of a ligand (EGF-like or NRG) to the…

Lesion Immunohistochemistry Molecular characteristics Nodular fasciitis Pos: SMA, MSA, vimentin, calponin and desmin (rare) Deletion of chromosome 2 and 13, der(15), t(2; 15)(q31; q26), tetraploidy and del (6), gains of…

Fig. 13.1 MicroRNA processing and the RISC complex. The gene encoding the microRNA is transcribed to produce a pri-miRNA which is cleaved by DROSHA to produce a pre-miRNA. The pre-miRNA is…

TNBC Subtype Immunohistochemistry Molecular characteristics Adenoid cystic carcinoma ER−/PR−/HER2− in >90 % C-KIT+, P63+, EGFR+HCM−, calponin—Ki67 low, TP53—low Topo IIα expression t(6, 9)(q22–23;p23–24) MYB-NFIB fusion gene No EGFR gene amplification No…

Fig. 1.1 Picture of a molecular breast imaging system. Courtesy of Jason Koshnitsky, Gamma Medica, Inc., Salem, NH Indications The indications for performance of a BSGI study include high-risk surveillance, alternative…

Fig. 18.1 This four-panel set of photomicrograph shows the histology displayed in sections of 4 distinct male breast cancers and demonstrates morphological heterogeneity in these tumours. All ×400 Gene expression studies…

Gene Chromosomal location Function Mode of inheritance Lifetime risk of developing breast cancer Other major cancer risk Clinical syndrome association TP53 17p13.1 Regulates expression of many genes by anti-proliferative mechanisms…

Fig. 6.1 Histologic grading of ductal carcinoma in situ (DCIS) It should be noted that while interobservor variability in the classification of DCIS has improved significantly since the adoption of the…