Tumor-Associated Macrophages and Cancer Development
Fig. 20.1 Two mechanisms proposed to explain the association between TAMs and tumorigenesis. (a) A large set of chemokines (CCL2 and others) and cytokines (G-CSF and so on) secreted by…
Dendritic Cell Vaccines for Cancer Therapy: Fundamentals and Clinical Trials
22. Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol. 2003;21:685–711.PubMed 23. Sallusto F, Schaerli P, Loetscher P, Schaniel C, Lenig D, Mackay CR, et al. Rapid…
Recent Advances in the Use of NK Cells Against Cancer
© Springer-Verlag Berlin Heidelberg 2015Nima Rezaei (ed.)Cancer Immunology10.1007/978-3-662-44946-2_18 18. Recent Advances in the Use of NK Cells Against Cancer Amy E. Gillgrass1 , Tamara Krneta1 and Ali A. Ashkar1 (1) Department of Pathology and Molecular Medicine, McMaster Immunology Research Center…
Gene Therapy and Virus-Based Cancer Vaccines
Gammaretrovirus vectors Lentivirus vectors Adenovirus vectors Adeno-associated virus vectors Herpes simplex virus-1 vectors Cloning capacity 7–7.5 kb 18 kb 37 Kb 4.9 kb Up to 152 kb (dependent on…
T Cell Immunotherapy: From Synthetic Biology to Clinical Practice
Primary concerns in the clinical utilization of CAR-modified T cells I. T lymphocyte population selection and culture (a) Mechanism of T cell activation (OKT3, CD3-CD28 beads) (b) Cytokines or small…
Combination of Chemotherapy and Cytokine Therapy in Treatment of Cancers
Cytokine Condition Chemotherapy Phase State Reference Outcome IL-2 Melanoma Dacarbazine II Ongoing NCT00553618 Melanoma +Cy II Ongoing NCT01833767 Breast cancer +Paclitaxel II Ongoing NCT01134250 Breast cancer +Doxorubicin II Ongoing NCT01131364 …
Hematopoietic Stem Cell Transplantation and Lymphodepletion for the Treatment of Cancer
Bone marrow Peripheral blood Cord blood Limiting factor HLA match HLA match Cell quantity Minimal HLA match 4/6 9/10 9/10 GVHD risk Yes Yes No Biggest risk GVHD GVHD…
Immunologic Approaches to Targeting Cancer Stem Cells
Tumor type Markers Reference Bladder ABCG2high SP (side population, Hoechst dye) [12] ALDH1high [13] Breast CD44+CD24−/low [10] ALDH1high [14] Colon CD133+ [15] EpCAMhigh CD44+ [16] ALDH1high [17] Gastric CD44+ [18]…
Cancer Stem Cells: Biology and Potential Therapeutic Applications
Fig. 8.1 Main signaling pathways involved in the molecular mechanisms underlying CSC control. The activation of these pathways following different stimuli results in the enhanced transcription of several genes (i.e.,…
Novel Strategy of Cancer Immunotherapy: Spiraling Up
Fig. 2.1 Schematic interaction of the effectors of innate and adaptive immunity. Abbreviations: TC tumor cell, DC dendritic cell, Th1 and Th2 T helper cells of types 1 and 2,…
