Immunotherapy for Pediatric Solid Tumors
62. Scursoni AM, Galluzzo L, Camarero S, Pozzo N, Gabri MR, de Acosta CM, et al. Detection and characterization of N-glycosylated gangliosides in Wilms tumor by immunohistochemistry. Pediatr Dev Pathol….
Immunopathology and Immunotherapy of Lymphoblastic Leukaemia
Stage Immune phenotype Target Early precursor HLA-DR, TdT, cCD22, CD79a, CD19 CD19 Blinatumomab Intermediate precursor (common) HLA-DR, TdT, cCD22, CD79a, CD19, CD10, CD20 (variable) CD19 Blinatumomab CD20 Rituximab, ofatumumab Late…
Immunotherapeutic Strategies for Multiple Myeloma
Mechanism Ag Short description of function Ab name Results of earlier trials Ongoing clinical trials mAbs targeting proteins involved in myeloma cell adhesion CS1 See text Elotuzumab Syndecan-1 (CD138) Cell…
Vaccination in Human Solid Tumors: Recent Progress in the Clinical Arena
1 Shared/self-/differentiation TAAs (e.g., Melan-A, PSA, CEA) 2 Shared/self-/cancer testis or germinal TAAs (e.g., MAGE, NY-ESO-1) 3 Universal TAAs (e.g., survivin, hIERI) 4 Mutated, unique TAAs The TAAs recognized by…
Immunopathology and Immunotherapy of Myeloid Leukemia
Fig. 5.1 Models of pathogenesis of AML. Three possible scenarios for the development of the LSC are shown. Hematopoietic stem cells (HSC) or myeloid progenitors (MP) or both populations are…
Role of γδ T Lymphocytes in Cancer Immunosurveillance and Immunotherapy
Species V segment usage Common VγVδ usage V(d) J diversity Day of exportation from the embryonic thymus Distribution Mouse Vγ1 Vγ1Vδ6.3 (liver) High From E18 onward Spleen, liver Vγ4 High…
Photodynamic Therapy and Antitumor Immune Response
Fig. 21.1 PDT induced effects. In tumors, cells loaded with PS upon excitation generate ROS species which leads to predominantly apoptotic and necrotic cell deaths. Tumor cell death is accompanied…
Novel Prognostic Biomarkers for Personalized Cancer Treatment
Fig. 3.1 Biomarkers have to be very prognostic for the specific physiopathological conditions inherent with the pathology. Being the chronicity of inflammation, the base for the genesis and the progression…
Immunotherapies Targeting a Tumor-Associated Antigen, 5T4 Oncofetal Glycoprotein
Fig. 23.1 Structure of 5T4 molecules. Human and mouse 5T4 analyzed by a homology modeling approach using the variable lymphocyte receptor A29 (PDB entry 2o6q) and energy minimized to produce…
Tumor Antigen and Epitope Identification for Preclinical and Clinical Evaluation
Groups of tumor antigens Antigens Cancer type Cancer testis (CT) MAGE1-3 and -6 Melanoma, breast, head/neck HAGE, GAGE, NY – ESO – 1, BAGE, XAGE Bladder, gastric and lung, head/neck,…
