Oncohema Key

Fig. 23.1 Structure of 5T4 molecules. Human and mouse 5T4 analyzed by a homology modeling approach using the variable lymphocyte receptor A29 (PDB entry 2o6q) and energy minimized to produce…

Groups of tumor antigens Antigens Cancer type Cancer testis (CT) MAGE1-3 and -6 Melanoma, breast, head/neck HAGE, GAGE, NY – ESO – 1, BAGE, XAGE Bladder, gastric and lung, head/neck,…

Ag category Examples Expression in cancer Tissue differentiation Ags Mclan-A/MART-1, gp100, tyrosinase, TRP-1, TRP-2 Melanoma PSA Prostate carcinoma Prostate-specific membrane Ag (PSMA) Prostate carcinoma MUC-1 Particular adenocarcinomas MUC-16 (CA-125) Mainly…

Fig. 22.1 Simplified scheme of tumor progression. During progression, cancer cells recruit inflammatory cells and “educate” their phenotype (in the case of macrophages, from M1 to M2). The phenotype abbreviated…

Radionuclide T 1/2 (h)a Emissionsb Emax (keV)c Range max in soft tissue (mm)c Usual labeling method Technetium-99 m 6.0 γ 140  Direct labeling or N2S2 or N3S complexes Indium-111 67…

Cancer type TLRs expressed Basal cell carcinoma TLR7 Breast cancer TLR2, 3, 4, 5, 7, and 9 Brain cancer TLR2 and 4 Colorectal cancer TLR2, 3, 4, 5, 7, and…

Fig. 15.1 Tumor growth, CTL activity, IFN-γ expression; a comparison in B cell-depleted mice (BCDM), B cell-reconstituted BCDM, and immunocompetent wild-type (WT) mice. Mice were subcutaneously injected with 106 EMT-6…

Fig. 14.1 Schematic representation of adoptive T cell transfer therapy using T cells genetically modified with chemokine receptor. Tumor mass is excised from the patient and TILs (tumor-infiltrating lymphocytes) are…

Type Application Target Alemtuzumab Chronic lymphocytic leukemia CD52 Bevacizumab Anti-angiogenic therapy Vascular endothelial growth factor (VEGF) Cetuximab Colorectal, head, and neck cancer Epidermal growth factor receptor (EGFR) Gemtuzumab Acute myeloid…