86. Rao H-L, Chen J-W, Li M, et al. Increased intratumoral neutrophil in colorectal carcinomas correlates closely with malignant phenotype and predicts patients’ adverse prognosis. PLoS One. 2012;7:e30806.PubMedCentralPubMed 87. Algars…
Fig. 7.1 The figure demonstrates the immune environment of HRS cells in HL, as well as the antibodies located on the cell surface which are considered potential targets for immunotherapy…
62. Scursoni AM, Galluzzo L, Camarero S, Pozzo N, Gabri MR, de Acosta CM, et al. Detection and characterization of N-glycosylated gangliosides in Wilms tumor by immunohistochemistry. Pediatr Dev Pathol….
Stage Immune phenotype Target Early precursor HLA-DR, TdT, cCD22, CD79a, CD19 CD19 Blinatumomab Intermediate precursor (common) HLA-DR, TdT, cCD22, CD79a, CD19, CD10, CD20 (variable) CD19 Blinatumomab CD20 Rituximab, ofatumumab Late…
Mechanism Ag Short description of function Ab name Results of earlier trials Ongoing clinical trials mAbs targeting proteins involved in myeloma cell adhesion CS1 See text Elotuzumab Syndecan-1 (CD138) Cell…
1 Shared/self-/differentiation TAAs (e.g., Melan-A, PSA, CEA) 2 Shared/self-/cancer testis or germinal TAAs (e.g., MAGE, NY-ESO-1) 3 Universal TAAs (e.g., survivin, hIERI) 4 Mutated, unique TAAs The TAAs recognized by…
Fig. 5.1 Models of pathogenesis of AML. Three possible scenarios for the development of the LSC are shown. Hematopoietic stem cells (HSC) or myeloid progenitors (MP) or both populations are…
Species V segment usage Common VγVδ usage V(d) J diversity Day of exportation from the embryonic thymus Distribution Mouse Vγ1 Vγ1Vδ6.3 (liver) High From E18 onward Spleen, liver Vγ4 High…
Fig. 21.1 PDT induced effects. In tumors, cells loaded with PS upon excitation generate ROS species which leads to predominantly apoptotic and necrotic cell deaths. Tumor cell death is accompanied…
Fig. 3.1 Biomarkers have to be very prognostic for the specific physiopathological conditions inherent with the pathology. Being the chronicity of inflammation, the base for the genesis and the progression…
