Systemic Therapy for Colon Cancer
15 Systemic Therapy for Colon Cancer Khaled El-Shami, Sujatha Nallapareddy, Wells Messersmith KEY POINTS • Systemic therapy for colorectal cancer is rapidly changing, with six new drugs introduced during the…
Vaccines and Immunotherapy
19 Vaccines and Immunotherapy Ajay Jain, Richard Schulick KEY POINTS • Immunotherapy is a therapeutic strategy in which a patient’s immune responses are modulated to eradicate malignant cancer cells. •…
Chemoprevention of Colorectal Cancer
6 Chemoprevention of Colorectal Cancer Melissa A. Munsell, Francis M. Giardiello KEY POINTS • The chemopreventive effect of nonsteroidal anti-inflammatory drugs (NSAIDs) is supported by in vitro experiments, animal models,…
Limited Resection: Indications, Techniques, and Outcomes of Transanal Excision and Transanal Endoscopic Microsurgery
12 Limited Resection: Indications, Techniques, and Outcomes of Transanal Excision and Transanal Endoscopic Microsurgery Elizabeth C. Wick KEY POINTS • Local excision is applicable in a select subset with early…
Endoscopic Techniques in Colorectal Neoplasia
13 Endoscopic Techniques in Colorectal Neoplasia Eun Ji Shin, Samuel A. Giday KEY POINTS • Endoscopic techniques that are discussed include endoscopic resection and colonic stenting. • Endoscopic resections are…
Stool and Blood Sampling for Early Detection of Colorectal Cancer
9 Stool and Blood Sampling for Early Detection of Colorectal Cancer Jason K. Sicklick, Nita Ahuja KEY POINTS • Screening methods have been applied for the detection of premalignant colonic…
Radiation Therapy for Colorectal Adenocarcinoma: External Beam and Intraoperative Radiation Therapy
16 Radiation Therapy for Colorectal Adenocarcinoma: External Beam and Intraoperative Radiation Therapy Joseph M. Herman, Timothy M. Pawlik KEY POINTS • Despite aggressive surgical management, up to 40% of patients…
Presentation and Initial Evaluation of Colorectal Cancer
2 Presentation and Initial Evaluation of Colorectal Cancer Susan Tsai, Susan L. Gearhart KEY POINTS • In the United States, nearly 85% of patients with colorectal cancer (CRC) are symptomatic…
Colonoscopy and Flexible Sigmoidoscopy in Colorectal Cancer Screening and Surveillance
8 Colonoscopy and Flexible Sigmoidoscopy in Colorectal Cancer Screening and Surveillance Michelle N. Zikusoka, John H. Kwon KEY POINTS • Persons with average risk for colorectal cancer should undergo flexible…
Fecal Occult Blood Test
7 Fecal Occult Blood Test Michel I. Kafrouni, John H. Kwon KEY POINTS • Screening with the fecal occult blood test (FOBT) is less useful in the prevention of cancer…
