Expected immunophenotype Follicular lymphoma CD19+, CD20+, IgM ± IgD, monotypic sIg+, CD10+, bcl-6+, bcl-2 ±, HGAL, LMO2; associated with CD21+/CD23+ follicular dendritic cell meshworks Lymphoplasmacytic lymphoma CD19+, CD20+, monotypic sIg+, IgM, CD22+,…
IgG IgA IgM IgD IgE Heavy chain Classes Gamma (γ) Alpha (α) Mu (μ) Delta (δ) Epsilon (ε) Subclasses IgG1, IgG2, IgG3, IgG4 IgA1, IgA2 None None None Light…
Fig. 7.1 Peripheral blood film showing typical CLL cells and a smear cell (1,000× magnification) Fig. 7.2 Peripheral blood film showing prolymphocytes along with typical CLL cells (1,000× magnification) In…
Fig. 16.1 ALL: PAS reaction. Note the block-like reaction product Fig. 16.2 AML (FABM0). Blasts with no differentiation. Peroxidase negative but with positive myeloid antigens by flow cytometry Fig. 16.3…
Feature Type of heavy-chain disease α γ μ Year described 1968 1964 1969 Incidence Rare Very rare Very rare Age at diagnosis Young adult (<30 years) Older adult (60–70 years)…
Low grade A. Malignant lymphoma, small lymphocytic Consistent with chronic lymphocytic leukemia Plasmacytoid B. Malignant lymphoma, follicular, predominantly small cleaved cell Diffuse areas Sclerosis C. Malignant lymphoma, follicular, mixed small…
Fig. 3.1 Peripheral blood (PB) film from a patient with chronic myelogenous leukemia with an unusually high white cell count showing an increase of neutrophils, eosinophils, basophils, and granulocyte precursors….
Fig. 37.1 An enlarged tongue in a patient with AL amyloidosis Fig. 37.2 Clinical presentation of classic vascular purpura The Congo Red Stain The only accepted diagnostic test to validate…
Fig. 14.1 The two-hit model of acute leukemogenesis. This model hypothesizes that AML and ALL are the consequence of a combination of at least two broad classes of mutations. Class…
Cognitive Evaluation of the danger versus one’s coping resources. Focus is on the perceived threat while extraneous detail environmental details are blocked out (tunnel vision). For example, a patient may…
