Fig. 16.1 ALL: PAS reaction. Note the block-like reaction product Fig. 16.2 AML (FABM0). Blasts with no differentiation. Peroxidase negative but with positive myeloid antigens by flow cytometry Fig. 16.3…
Feature Type of heavy-chain disease α γ μ Year described 1968 1964 1969 Incidence Rare Very rare Very rare Age at diagnosis Young adult (<30 years) Older adult (60–70 years)…
Low grade A. Malignant lymphoma, small lymphocytic Consistent with chronic lymphocytic leukemia Plasmacytoid B. Malignant lymphoma, follicular, predominantly small cleaved cell Diffuse areas Sclerosis C. Malignant lymphoma, follicular, mixed small…
Fig. 3.1 Peripheral blood (PB) film from a patient with chronic myelogenous leukemia with an unusually high white cell count showing an increase of neutrophils, eosinophils, basophils, and granulocyte precursors….
Fig. 37.1 An enlarged tongue in a patient with AL amyloidosis Fig. 37.2 Clinical presentation of classic vascular purpura The Congo Red Stain The only accepted diagnostic test to validate…
Fig. 14.1 The two-hit model of acute leukemogenesis. This model hypothesizes that AML and ALL are the consequence of a combination of at least two broad classes of mutations. Class…
Cognitive Evaluation of the danger versus one’s coping resources. Focus is on the perceived threat while extraneous detail environmental details are blocked out (tunnel vision). For example, a patient may…
Earliest definition Current definition ECOG’s new definition Myeloid Myeloid Myeloid HLA-DR NEG HLA-DR NEG HLA-DRNEG CD34 HLA CD34 NEG CD11a NEG CD15 NEG CD18NEG CH15s POS CD133 NEG CD9 POS…
Fig. 28.1 US myeloma mortality rates (age-adjusted, 2000 U.S. standard) by race and sex, 1953–1957 to 2003–2006 Rates specific for blacks, available since the early 1970s, are higher than rates…
Disorder Disease definition References Monoclonal gammopathy of undetermined significance (MGUS) All 3 criteria must be met: •Serum monoclonal protein <3 g/dL •Clonal bone marrow plasma cells <10 %, and •Absence…
