Hematopoietic Stem Cell Sources and Donor Selection
Fig. 3.1 Suggested algorithm for hematopoietic stem cell donor selection. MUD matched unrelated donor, UCB umbilical cord blood, URD unrelated donor a. HLA is the name of the set of…
Overview of Hematopoietic Stem Cell Transplantation
© Springer Science+Business Media, LLC 2015Richard T. Maziarz and Susan Schubach Slater (eds.)Blood and Marrow Transplant Handbook10.1007/978-3-319-13832-9_1 1. Overview of Hematopoietic Stem Cell Transplantation Richard T. Maziarz1 (1) Center for Hematologic Malignancies, Adult Blood and Marrow…
Pre-transplant Medical Evaluation
Disease Autologous Allogeneic AML X X ALL – X MDS – X CML – X Lymphoma X X Myeloma X X Germ cell X – Bone marrow failure – X…
Conditioning Regimens
Regimen Disease states treated Comments Cy + ATG + / – TBI Aplastic anemia TBI added for unrelated donors (URD) tBu–Cy AML, ALL, CLL, CML, NHL, MM, MDS The busulfan exposure target varies by disease…
Social Work: Evaluation and Support
Organization URL Transplant resources Be the match www.marrow.org Blood and marrow transplant information network (BMT Infonet) www.bmtinfonet.org BMT support online www.bmtsupport.org Explore BMT www.explorebmt.org National bone marrow transplant link…
Mantle Cell Lymphoma
Better prognosis Poorer prognosis MIPIa score (Geisler et al. 2010) Low Intermediate or high MIPI-bb score (Schaffel et al. 2010) Low Intermediate or high Posttreatment MRDc (Pott et al….
Cytogenetics
Fig. 2.1 Application of FISH in lymphoma diagnostics and research. (a) Scheme of the dual-color, break-apart probe for BCL6 translocations (www.abbottmolecular.com); Scheme of the dual-color, dual-fusion translocation probe for the…
CNS Lymphoma
Fig. 11.1 A rare case of primary CNS lymphoplasmacytic lymphoma demonstrating a perivascular lymphoid infiltrate (10×) composed of lymphoplasmacytic cells (400×) Fig. 11.2 Lymphoplasmacytic lymphoma from Fig. 11.1 showing the…
Cutaneous T-Cell Lymphoma
Indolent subtypes Frequency (%) Aggressive subtypes Frequency (%) Mycosis fungoides variants and subtypes 61 Sézary syndrome 4 Folliculotropic mycosis fungoides 6 Adult T-cell leukemia/lymphoma <1 Pagetoid reticulosis <1 Extranodal NK/T-cell…
Primary Cutaneous B-Cell Lymphomas
T T1: Solitary skin involvement T1a: A solitary lesion <5 cm diameter T1b: A solitary >5 cm diameter T2: Regional skin involvement: multiple lesions limited to one body region or…
