Secondary Malignancies
Alkylating agents Topoisomerase II inhibitors Latency 3–8 years 2–3 years Incidence 2–20 % 2–12 % Myelodysplastic phase Present Absent FAB type M1, M2 M4, M5 Cytogenetics 5-, 7-, 5q-, 7q- 11q23…
Psychiatric Complications
Patient condition Suggested antidepressant drug of choice Depression with anxiety or agitation Paroxetine (Paxil®) Depression with lethargy and amotivation Fluoxetine (Prozac®), buproprion (Wellbutrin®), or venlafaxine (Effexor®) Preexisting cardiac disease Congestive…
Women’s Hormonal Health Issues
Composition Product name FDA-approved dosage Vaginal creams 17β-estradiol Estrace vaginal cream® Initial: 2–4 g/day for 1–2 weeks maintenance: 1 g/1–3 times/week Conjugated estrogens Premarin vaginal cream® For VVA: 0.5–2 g/day for 21 day…
Thrombotic Microangiopathies
Ruutu T, Barosi G, Benjamin RJ, Clark RE, George JN, Gratwohl A, et al. European Group for Blood and Marrow Transplantation; European LeukemiaNet. Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy:…
Endocrine Complications in Childhood Cancer Survivors
Alkylating agents Busulfan Cisplatin Cyclophosphamide Ifosfamide Mechlorethamine Melphalan Nitrosureas BCNU (carmustine) CCNU (lomustine) Procarbazine Thiotepa Primary factors associated with late endocrine complications are as follows: 1. Radiotherapy: the involved field,…
Kidney Disease in Hematopoietic Stem Cell Transplantation
(1) Portland Veterans Administration Medical Center, Oregon Health & Science University, 3710 SW US Veterans Hospital Road, P3NEPH, 97239 Portland, OR, USA KeywordsAcute kidney injuryChronic kidney diseaseChronic kidney disease in…
Cardiovascular Complications
Fig. 23.1 Standard approaches to acute atrial fibrillation b. Rate controlling agents (all can cause hypotension and bradycardia and should be administered in a monitored setting) i. Metoprolol 5 mg…
Oral Complications
Grade WHOa NCI-CTCb Bearman Grade 0 No oral abnormalities No oral abnormalities No oral abnormalities Grade 1 Oral soreness +/− erythema without ulceration; able to tolerate regular diet Erythema Pain…
Gastrointestinal Complications
Grade Diarrhea 1 Increase of < 4 stools per day over baseline; mild increase in ostomy output compared to baseline 2 Increase of 4–6 stools per day over baseline; IV fluid…
Chronic Graft-Versus-Host Disease
Organ or site Diagnostic (adequate for the diagnosis of cGvHD) Distinctive (seen in cGvHD but not aGvHD; insufficient to establish cGvHD diagnosis) Other features (cannot be used to establish a…
