Bone-Targeted Agents
Fig 15.1 Mechanism of action of bisphosphonate, denosumab, and anti-androgen on the bone metastases “vicious cycle.” OCLs osteoclasts, OBLs osteoblasts The efficacy of bisphosphonate treatment on patients with bone metastatic…
Markers of Bone Turnover in Bone Metastasis from Prostate Cancer
Fig. 2.1 Bone turnover is usually very high in prostate cancer (PC) patients for many reasons (aging, vitamin D deficiency, androgen deprivation therapy, or abiraterone or enzalutamide, cytokines released from…
Bone Metastases from Prostate Cancer: Radiotherapy
Fig. 14.1 Treatment delivery using portal imaging with digitally reconstructed radiograph (DRR) (a) and cone beam CT (b) to improve target visibility Fig. 14.2 Comparison between conventional planning with 3D-CRT…
Multidisciplinary Approach of Prostate Cancer Patients
Rationale and definition of MDT Promotion of MDT considered as an ethical priority, given the benefits of MDT and the imperative to provide all patients with the best possible care…
Economic Impact of Prostate Cancer Bone Metastases
Skeletal-related event Mean cost per skeletal-related event (€) Germany Italy Spain UK Non-vertebral fracture 1,720 2,087 3,209 2254 Vertebral fracture 2,124 2,142 6,968 1,015 Radiation to bone 1,694 2,461 2,378…
Biology and Pathophysiology of Bone Metastasis in Prostate Cancer
Fig. 1.1 Histopathology of bone metastasis (BMT) from prostate cancer (PC). In the same patient, BMTs are heterogeneous, with predominantly blastic (1) and predominantly lytic metastases (2). Furthermore, as shown…
New Frontiers in Treatment
© Springer International Publishing Switzerland 2017Francesco Bertoldo, Francesco Boccardo, Emilio Bombardieri, Laura Evangelista and Riccardo Valdagni (eds.)Bone Metastases from Prostate Cancer 10.1007/978-3-319-42327-2_17 17. New Frontiers in Treatment Sergio Bracarda1 , Alketa Hamzaj1 and Kalliopi Andrikou1 (1) Medical Oncology, Department of Oncology Azienda…
Bone-Seeking Radionuclide for Therapy
Type of decay Particle/photon Relative mass (AMU) Charge Typical LET (kV/μm) Alpha Helium nucleus 4 +2 60–300 Beta Electron (or positron) 1/2000 −1 electron (+1 positron) 0.1–1 Gamma Photon 0…
Combinations of Hormonal Therapy and Chemotherapy
Fig. 12.1 Representation of two models of development of castration-resistant prostate cancer (CRPC) from castration-sensitive prostate cancer (CSPC). ADT androgen deprivation therapy. Androgen-dependent prostate cancer cells are represented in blue,…
Chemotherapy
© Springer International Publishing Switzerland 2017Francesco Bertoldo, Francesco Boccardo, Emilio Bombardieri, Laura Evangelista and Riccardo Valdagni (eds.)Bone Metastases from Prostate Cancer 10.1007/978-3-319-42327-2_11 11. Chemotherapy Giovanni Luca Ceresoli1 , Maria Bonomi1 and Maria Grazia Sauta1 (1) Department of Medical Oncology, Cliniche Humanitas Gavazzeni, Bergamo, Italy…
