Fig. 3.1 Growth factor independence leads to sustained signalling in pathways that control essential biological functions. Binding of ligand to the extracellular ligand-binding domain leads to receptor dimerisation and activation…
Author No. of Pts Treatment Response rate (%) Median survival (months) First–line treatment chemotherapeutic agents Jacobs 245 PF P F 32a 17 13 5.5 5.0 6.1 Forastiere 277 PF CF…
Regimens N ORR (%) Median survival (months) Reference Cisplatin/5-FU 249 32 % 5.5 months [26] vs. Cisplatin 17 % 5 months vs. 5-FU 13 % 6.1 months Cisplatin/methotrexate/bleomycin/vincristine…
Tracer First author, year Type Target/process 18F-FMISO Rajendran, 2006 [14] Nitroimidazole Hypoxia 18F-FAZA Mortensen, 2012 [15] Nitroimidazole Hypoxia 18F-HX4 Zegers, 2015 [16] Nitroimidazole Hypoxia 18F-EF5 Komar, 2014 [17] Nitroimidazole Hypoxia…
The broken line or box is meant to signify the existential element to health and illness. One should consider the total needs of the patient and not just their pain…
© Springer International Publishing Switzerland 2017Jan B. Vermorken, Volker Budach, C. René Leemans, Jean-Pascal Machiels, Piero Nicolai and Brian O’Sullivan (eds.)Critical Issues in Head and Neck Oncology10.1007/978-3-319-42909-0_19 19. Symptoms at End-of-Life of Head and Neck Cancer Patients Dirk Schrijvers1 (1)…
© Springer International Publishing Switzerland 2017Jan B. Vermorken, Volker Budach, C. René Leemans, Jean-Pascal Machiels, Piero Nicolai and Brian O’Sullivan (eds.)Critical Issues in Head and Neck Oncology10.1007/978-3-319-42909-0_18 18. Quality of Life Issues Susanne Singer1 (1) Division of Epidemiology and Health…
Mechanism Specification 1. Reduced antigen processing and presentation Downregulation or mutation of HLA class molecules 2. Tumour-permissive cytokine profile Increase of immunosuppressive cytokines: TGF-β, IL-6 Decrease of stimulatory cytokines: IL-2,…
Assessment of functioning Social assessment Definition: ability to live independently at home and in the community, physical performance (mobility, balance, fall risk) Definition: adequate social support to undergo treatment Measurement:…
© Springer International Publishing Switzerland 2017Jan B. Vermorken, Volker Budach, C. René Leemans, Jean-Pascal Machiels, Piero Nicolai and Brian O’Sullivan (eds.)Critical Issues in Head and Neck Oncology10.1007/978-3-319-42909-0_12 12. Salvage Surgery of Head and Neck Cancer C. René Leemans1 (1) VU University…
