Androgen inhibitors Abiraterone FDA approval For metastatic CRPC before chemotherapy For metastatic CRPC following docetaxel Orteronel (TAK-700) Phase III Maintenance therapy in patients with mCRPC previously treated with novel hormonal…
Study No of patients Randomization Results RTOG 85-31 [31] 977 RT vs. RT + LHRHa (continuous) Combined arm is better in all end points RTOG 86-10 [32] 456 RT vs. RT + 4 month CAB…
© Springer International Publishing AG 2017Gokhan Ozyigit and Ugur Selek (eds.)Principles and Practice of Urooncologyhttps://doi.org/10.1007/978-3-319-56114-1_17 17. Adjuvant or Salvage Radiotherapy in Postoperative Prostate Cancer Ugur Selek1, 2, Yasemin Bolukbasi1, 2 and Deborah A. Kuban2 (1) Department of Radiation Oncology,…
© Springer International Publishing AG 2017Gokhan Ozyigit and Ugur Selek (eds.)Principles and Practice of Urooncologyhttps://doi.org/10.1007/978-3-319-56114-1_6 6. Targeted Therapies and Immunotherapy in Bladder Cancer Mehmet Ali Nahit Şendur1 and Sercan Aksoy2 (1) Department of Medical Oncology, Ankara Yıldırım Beyazıt University,…
Fig. 7.1 A model of PCa progression. PCa starts as a localized tumor. In its natural progression, it typically metastasizes to the lymph nodes and then the bone, producing bone-forming…
Fig. 9.1 Biomarker Classification. Adapted from Mishra A, Verma M. Cancer biomarkers: are we ready for the prime time? Cancers. 2010;2(1):190–208. doi:10.3390/cancers2010190 DNA Biomarkers The most fundamental event in the…
© Springer International Publishing AG 2017Yuzhuo Wang, Dong Lin and Peter W. Gout (eds.)Patient-Derived Xenograft Models of Human Cancer Molecular and Translational Medicine10.1007/978-3-319-55825-7_1 1. Patient-Derived Tumor Xenografts: Historical Background Dong Lin1, 2, 3 , Xinya Wang1, Peter W. Gout4, 3 and…
Fig. 2.1 Overview of the main steps in establishing PDXs. Step 1: High-quality patient specimens are obtained from various stages of cancer progression, from benign tissue to metastases, using a…
Fig. 5.1 Efficacy study of S-1 in four gastric PDX models. a and b show that GAPF155 and GAPF157 were sensitive to S-1; c and d show that GAPF161 and…
Fig. 4.1 Overturning the aspiration needle and tapping the material on the slide can often facilitate removal of partially clotted specimen in the needle hub Once a small amount of…
