Fig. 36.1 Schematic representation of target-based drug discovery and development process . Drug discovery process typically begins with the identification and the validation of the target in vitro and in…
Fig. 24.1 Nucleotide excision repair and the DNA damage response from radiation and chemicals, oncogene driven replication and virus infections. Adapted with modifications from ref. [33]. The DDR has been…
Fig. 14.1 Effect of allele frequency and relative risk on the required sample size to generate 90 % power to show significant associations (P = 0.01) for co-dominant susceptibility alleles,…
Fig. 41.1 Activating mutations in K-Ras occurring early on during pancreatic cancer development lead to higher proliferating rates of affected cells. While this may trigger the cell surveillance system that…
Fig. 4.1 Early chromosome analysis and molecular cytogenetics. (a) Photograph of Theodor Boveri (1862–1915). Boveri was a professor of zoology in Würzburg, Germany. Combining his theory that chromosomes carry genetic…
Fig. 16.1 Graphical display of the most common epigenetic changes in CpG islands of tumor suppressor genes and DNA repeats in normal and cancer cells. 16.3 Technical Approaches to Detect…
Date approved Drug Place Disease May 2003 Bortezomib USA (FDA) Multiple myeloma December 2003 Thalidomide Australia Multiple myeloma February 2004 Bevacizumaba USA (FDA) Colorectal cancer November 2004 Erlotinib USA (FDA)…
© Springer Science+Business Media New York 2017William B. Coleman and Gregory J. Tsongalis (eds.)The Molecular Basis of Human Cancer10.1007/978-1-59745-458-2_29 29. Molecular Basis of Skin Carcinogenesis Alessia Pacifico1 , Giovanni Leone1 and Honnavara N. Ananthaswamy2 (1) Phototherapy Unit, S. Gallicano Dermatological…
SCLC NSCLC Frequency ~20–25 % ~75–80 % Histology Scant cytoplasm, small hyperchromatic nuclei, fine chromatin, indistinct nucleoli, tumor in sheets Abundant cytoplasm, pleomorphic nuclei, coarse chromatin, prominent nucleoli, squamous/glandular…
© Springer Science+Business Media New York 2017William B. Coleman and Gregory J. Tsongalis (eds.)The Molecular Basis of Human Cancer10.1007/978-1-59745-458-2_27 27. The Molecular Basis of Prostate Carcinogenesis Smitha Dutt1 and Allen C. Gao1 (1) Department of Urology and Cancer…
