Epigenetic Mechanisms in Cancer Development
Fig. 16.1 Graphical display of the most common epigenetic changes in CpG islands of tumor suppressor genes and DNA repeats in normal and cancer cells. 16.3 Technical Approaches to Detect…
Therapeutic Agents That Inhibit Angiogenesis
Date approved Drug Place Disease May 2003 Bortezomib USA (FDA) Multiple myeloma December 2003 Thalidomide Australia Multiple myeloma February 2004 Bevacizumaba USA (FDA) Colorectal cancer November 2004 Erlotinib USA (FDA)…
Molecular Basis of Skin Carcinogenesis
© Springer Science+Business Media New York 2017William B. Coleman and Gregory J. Tsongalis (eds.)The Molecular Basis of Human Cancer10.1007/978-1-59745-458-2_29 29. Molecular Basis of Skin Carcinogenesis Alessia Pacifico1 , Giovanni Leone1 and Honnavara N. Ananthaswamy2 (1) Phototherapy Unit, S. Gallicano Dermatological…
Molecular Basis of Lung Carcinogenesis
SCLC NSCLC Frequency ~20–25 % ~75–80 % Histology Scant cytoplasm, small hyperchromatic nuclei, fine chromatin, indistinct nucleoli, tumor in sheets Abundant cytoplasm, pleomorphic nuclei, coarse chromatin, prominent nucleoli, squamous/glandular…
The Molecular Basis of Prostate Carcinogenesis
© Springer Science+Business Media New York 2017William B. Coleman and Gregory J. Tsongalis (eds.)The Molecular Basis of Human Cancer10.1007/978-1-59745-458-2_27 27. The Molecular Basis of Prostate Carcinogenesis Smitha Dutt1 and Allen C. Gao1 (1) Department of Urology and Cancer…
Hereditary Breast and Ovarian Cancer
Risk factor Relative risk (RR) Family history First-degree relative with BC 2.40 Mother with BC before the age of 50 2.41 Sister with BC before the age of 50 3.18…
Sporadic Cancers
Fig. 21.1 Clinical outcomes of HPV vaccination trials in an intention-to-treat meta-analysis. Adapted from [35]. Another form of cancer with an infectious etiology is gastric cancer. Helicobacter pylori (H. pylori)…
Viral Mechanisms in Human Carcinogenesis
© Springer Science+Business Media New York 2017William B. Coleman and Gregory J. Tsongalis (eds.)The Molecular Basis of Human Cancer10.1007/978-1-59745-458-2_19 19. Viral Mechanisms in Human Carcinogenesis Paul F. Lambert1 (1) McArdle Laboratory for Cancer Research, Department of Oncology,…
MicroRNAs and Cancer
Tumor type miRNAs Comments Reference(s) Brain, GBM miR-21, miR-221, miR-222, (up) miR-21 upregulated in all high-grade tumors [45, 47] Breast cancer miR-21, miR-155b (up) miR-125b, miR-145 (down) Expression levels correlate…
Novel Cancer Therapies Targeting Angiogenesis
© Springer Science+Business Media New York 2017William B. Coleman and Gregory J. Tsongalis (eds.)The Molecular Basis of Human Cancer10.1007/978-1-59745-458-2_11 11. Novel Cancer Therapies Targeting Angiogenesis Monte S. Willis1 and Nancy Klauber-DeMore2 (1) Department of Pathology and Laboratory Medicine,…
