Reactions on the Hands and Feet
Reactions on the Hands and Feet Louise M. Gresham Maxwell B. Sauder Toxicities from anticancer therapies affecting the hands and feet are common and can be divided into three main…
Pigmentary Alterations
Pigmentary Alterations Amina Bougrine Pigmentary alterations caused by anticancer therapies can be seen in any phototype but are more frequent and prolonged in darker phototypes. They are rarely specific to…
Sclerosing Reactions
Sclerosing Reactions Jordan Taylor Said Cecilia Alejandra Larocca Sclerosing reactions are a rare set of cutaneous toxicities that can be caused by chemotherapy, immunotherapy, and radiotherapy—each with a unique presentation….
Edematous Reactions
Edematous Reactions Jared Seth Kahn David X. Gao Sandhya Deverapalli Edema occurs when there is a pathologic accumulation of fluid in either the interstitial spaces or an intracellular compartment. Various…
Erythroderma
Erythroderma Michelle S. Lee Vinod E. Nambudiri Erythroderma is typically defined as diffuse redness affecting over 80% to 90% of the body’s surface area (Figure 11.1). It is a reaction…
Purpuric Reactions
Purpuric Reactions Jasmine Rana Bernice Y. Kwong Purpura is due to red blood cells extravasating into the skin or mucous membranes. Purpuric lesions present as deep red to purple in…
Panniculitis-Like Reactions
Panniculitis-Like Reactions Amanda J. Shelley Katherine A. McDonald Anna Kristine Dewan Panniculitis is an uncommon reaction that may occur secondary to cytotoxic chemotherapy, immune checkpoint inhibitors, or small molecule inhibitors….
Bullous Reactions
Bullous Reactions Rohit Gupta Anisha B. Patel Bullous reactions represent a group of skin toxicities characterized by fluid-filled vesicles or bullae with varying localized or diffuse presentations depending on the…
Intertriginous Reactions
Intertriginous Reactions Rachel Reingold Alina Markova An intertriginous reaction pattern may present as erythematous, desquamative, scaly, dusky or eroded patches or plaques commonly affecting one or more folds in the…
Acneiform Reactions
Acneiform Reactions Michelle S. Lee Vinod E. Nambudiri Acneiform eruptions are a relatively common skin toxicity, occurring across several drug classes, and are observed in up to 80% of patients…
