Antimetabolites
Antimetabolites Sheila Shaigany Paul I. Schneiderman Antimetabolites represent a broad class of chemotherapy agents that halt tumor growth by disrupting cellular division in the S phase of the cell cycle….
Topoisomerase Inhibitors
Topoisomerase Inhibitors Abdulhadi Jfri Christopher Iriarte Victor Huang Topoisomerases are enzymes involved in DNA structure, specifically in breaking and rejoining the phosphodiester backbone of double stranded DNA.1 Topoisomerase I inhibitors…
Alkylating Agents
Alkylating Agents Sheila Shaigany Alkylating agents are highly reactive cytotoxic agents that damage DNA by covalently attaching an alkyl group to guanine molecules present in DNA. This leads directly to…
Severe Cutaneous Adverse Reactions
Severe Cutaneous Adverse Reactions Elisa M. Schunkert Andrew C. Walls Severe cutaneous adverse reactions (SCARs) to drugs include several potentially lifethreatening conditions, such as: SJS/TEN (Stevens-Johnson syndrome/toxic epidermal necrolysis) SJS/TEN-like…
Inflamed Actinic Keratoses
Inflamed Actinic Keratoses Emma H. Weiss Caroline A. Nelson Jonathan S. Leventhal Inflammation of clinical and subclinical actinic keratoses is commonly seen with systemic administration of antimetabolites, such as 5-fluorouracil,…
Hair and Nail Abnormalities
Hair and Nail Abnormalities Jennifer E. Yeh Jennifer T. Huang HAIR CHANGES Hair loss is one of the most common and distressing side effects of cancer treatment and can be…
Radiation Recall
Radiation Recall Stephanie W. Liu Radiation recall is an inflammatory skin reaction that occurs in a previously irradiated field. The recall is triggered by administration of certain pharmacologic agents sometime…
Oral Toxicities
Oral Toxicities Shaiba Sandhu Brittany A. Klein Sook Bin Woo Nathaniel Treister Herve Y. Sroussi Oral mucosal toxicities are a common finding in patients treated with a range of anticancer…
Reactions on the Hands and Feet
Reactions on the Hands and Feet Louise M. Gresham Maxwell B. Sauder Toxicities from anticancer therapies affecting the hands and feet are common and can be divided into three main…
