BTK Inhibitors
BTK Inhibitors Blake Elizabeth Brooks Elisa M. Schunkert Sherrie J. Divito Bruton tyrosine kinase (BTK) is a cytoplasmic nonreceptor tyrosine kinase that plays an integral role in signal transduction of…
Multikinase Inhibitors
Multikinase Inhibitors Karolina Mieczkowska Beth McLellan Multikinase inhibitors (MKIs) represent a diverse array of targeted chemotherapies (Table 33.1) that are used in the treatment of both solid and hematologic malignancies….
mTOR Inhibitors
mTOR Inhibitors Adam Faletsky Shaiba Sandhu Herve Y. Sroussi Lauren M. Guggina The mammalian target of rapamycin (mTOR) is an important factor in cell growth and survival. mTOR is a…
PI3-Kinase Inhibitors
PI3-Kinase Inhibitors Shaiba Sandhu Ashleigh Eberly Puleo Nicole R. LeBoeuf The phosphoinositide 3-kinase (PI3K) pathway is important in cell survival, proliferation, and differentiation1 and is frequently altered in human cancers;…
MEK Inhibitors
MEK Inhibitors Michael S. Chang Rebecca I. Hartman The mitogen-activated protein kinase (MAPK) pathway is highly implicated in aberrant signaling leading to carcinogenesis. Primary targets of this signaling cascade include…
BRAF Inhibitors
BRAF Inhibitors Jordan Talia Christine M. Cornejo Jesse Hirner BRAF is an oncogene encoding the BRAF protein, a component of the MAPK signaling pathway, that regulates cell proliferation, differentiation, survival,…
Epidermal Growth Factor Receptor (EGFR) Inhibitors
Epidermal Growth Factor Receptor (EGFR) Inhibitors Timothy M. Dang Daniela Kroshinsky The human epidermal growth factor receptor (HER) family of proteins is normally involved in cell growth and survival.1 HER1,…
Microtubule Inhibitors
Microtubule Inhibitors Timothy M. Dang Daniela Kroshinsky Microtubule inhibitors are comprised of largely two classes of chemotherapy—taxanes and vinca alkaloids. Taxanes are cytotoxic drugs that promote the polymerization of tubulin…
Anthracyclines
Anthracyclines Emma H. Weiss Caroline A. Nelson Jonathan S. Leventhal Anthracycline antibiotics are derived from Streptomyces species and are a commonly used cytotoxic treatment for both solid and hematologic malignancies…
