Highlights • Small molecule MIF inhibitor CPSI-1306 inhibits HNSCC growth in vivo . • CPSI-1306 potently inhibits T cell immunosuppression in the tumor microenvironment. • CPSI-1306 completely abrogates CTLA4, TIGIT…
Highlights • The immune TME in NPC is unsupervisedly dissected into “Immune Inflamed” and “Immune Deficient” subtypes. • Tertiary lymphoid structures (TLS) serve as better prognostic indicators than individual immune…
Highlights • ctDNA provided complementary information on actionable mutations to tissue biopsy. • ctDNA provided a comprehensive view of mutational landscape dynamics over time. • ctDNA-based molecular relapse detection has…
Highlights • Omitting prophylactic PEG and younger age associated with increased weight loss. • Higher risk of feeding tube duration with prophylactic PEG and older patients. • Prophylactic PEG did…
We wish to address the article entitled “Evaluation of the 10 %-rule in sentinel lymph node biopsy for clinically node-negative oral squamous cell carcinoma” by Tellman et al. . While the…
Highlights • Lymph node metastasis with extranodal extension was the most important prognostic factor. • Postoperative radiotherapy was associated with a lower risk of recurrence and a good prognosis. •…
Highlights • This study is the first to explore the efficacy and safety of the docetaxel, cisplatin, and capecitabine (TPC) regimen compared to GP and TPF. • Our findings indicate…
Highlights • The 10%-rule effectively identified metastatic sentinel nodes intraoperatively. • Applying the 10%-rule per neck side must be considered. • Raising the threshold is not advised, as this leads…
Highlights • The most common definition of delayed DTI is a time interval exceeding 30 days. • Delays in DTI over 30 days significantly reduce overall survival for head and…
Highlights • The first to analyze data retrospectively from pediatric PTC patients in a large medical unit with a particular focus on LNM patterns. • Comparative analysis between DSV-PTC and…
