Highlights • Combination systemic therapies (STs) including immuno-oncologic (IO) and VEGF-inhibiting (VEGFi) agents, predominantly tyrosine kinase inhibitors (TKI), have become the standard of care for metastatic clear cell carcinoma. •…
Highlights • Intravesical chemotherapy significantly reduces intravesical recurrence risk after NUT at 12 (OR 0.46) and 24 months (OR 0.41). • No statistically significant difference was found between single intra…
Highlights • Interrater agreement for both the 2019 and 2005 Bosniak classifications was comparable, showing fair to moderate agreement among resident raters. • The Bosniak 2019 version has increased the…
Highlights • Racial and insurance disparities impact access to integrated care. • Advanced cancer stages increase likelihood of integrated care. • Treatment and hospital factors minimally affect delivery of integrated…
Highlights • Identified 12 gut microbial taxa potentially linked to prostate cancer risk using MR analysis. • Employed robust statistical methods to ensure reliability of causal inference results. • Explored…
Highlights • In preclinical studies, it has been demonstrated that antihistamines may reverse macrophage immunosuppression, reactivate t-cell cytotoxicity, and enhance the immunotherapy response. • By use of individual patient data…
Highlights • Real-world study of US adults with la/mUC receiving first-line therapy. • Most received platinum-based chemotherapy (48.2%) or PD-1/L1 inhibitor (35.5%). • All first-line therapies had short survival, high…
Highlights • Initial trial results examining the efficacy of adjuvant immune checkpoint inhibitors in the setting of high-risk, resected muscle invasive urothelial carcinoma provided disparate results. • In this systematic…
Highlights • High grade and very high grade NMIBC has the potential to reoccur and progress and the BCG intravesical therapy is an adjuvant gold standard treatment. • Smoking impacts…
Highlights • The carcinogenic pathways of heavy metals/ trace elements in bladder cancer are studied. • They include alterations in MD, OS/ROS, and p38-MAPK pathway. • This data provides a…
