Keywords Tumor microenvironment, poxvirus, immunotherapy, immune escape Introduction The underlying hypothesis/strategy of our approach to immunotherapy is that by modulating the tumor microenvironment, we will be able to induce…
Keywords Cancer clinical trials, DNA, plasmid, vaccine Introduction Vaccination ranks among mankind’s greatest medical achievements. Routine immunization has eradicated small pox; virtually stamped out polio; and reduced the worldwide…
Keywords T cell receptor, chimeric antigen receptor, cancer, adoptive immunotherapy, gene therapy Introduction There are two types of immune responses: humoral immunity and cellular immunity. Humoral immunity is mediated…
Keywords Chemokines, antitumor immunity, immunotherapy, dendritic cells, tumor-infiltrating T cells Introduction Dendritic cells (DCs) are highly specialized, professional antigen-presenting cells (APCs) that activate naive T cells and are being…
Keywords Reovirus, chemotherapeutics, radiotherapy, cancer, clinical trials Introduction The use of viruses in the treatment of cancer resulted from the observation that clinical remission was occasionally seen in patients…
Keywords DTA-H19 plasmid, H19, oncofetal, cancer, transcriptional targeting, diphtheria toxin, tumor-specific promoter, hypoxia Introduction Reviewing brochures on the conventional cancer drugs in use today is undoubtedly a horrible and…
Keywords Cancer cells, Immune system, Dendritic cells, Genetically modified dendritic cell vaccination, Tumor antigens, Melanoma Introduction The immune system has the potential to control or eliminate cancer cells. This…
Keywords HSV, oncolysis, immune response, therapeutic transgene, safety, vector delivery, glioma Introduction Herpes simplex virus 1 (HSV-1) is a large, naturally neurotropic, double-stranded DNA virus. Primary infection with wild-type…
Keywords Oncolytic virus, cancer therapy, vaccinia virus, Lister strain vaccinia virus, immunotherapy Introduction Vaccinia virus (VV) has played a prominent role in one of the greatest achievements in medical…
Keywords Electroporation, gene therapy, cancer, nucleic acids, vaccine Introduction Electroporation or electropermeabilization (EP) is a physical method of introducing polar molecules such as DNA into eukaryotic cells through the…
