Keywords Gene therapy, hematopoiesis, cytidine deaminase, doxycycline, miRNA, Ara-C Background Transfer of Drug-Resistance Genes into Hematopoietic Stem Cells Given their ability to self-renewal, proliferate extensively, and differentiate into all…
Keywords Salmonella , genetic engineering, gene delivery, gene therapy, attenuation, toxicity, imaging Introduction Gene therapy is considered to be one of the most promising therapeutic approaches for treating cancer,…
Keywords IL-12, adenovirus, RheoSwitch®, activator ligand, dendritic cells, controlled expression, intratumoral, immunotherapy Introduction Tumors grow aggressively, are invasive, and may spread to distant metastatic sites, not only because of…
Keywords Gene therapy, drug resistance, glioblastoma, chemoprotection, in vivo selection, MGMT, hematopoietic stem cell, temozolomide Introduction Gene therapy was initially developed as an ideal treatment for defective single-gene diseases…
Keywords Dendritic cell vaccination, Major histocompatibility complex (MHC), CD11c + myeloid and CD11c − plasmacytoid dendritic cells, Clinical trials, Transfection, Viral transduction, Tumor cell hybrids, Pathogen-associated molecular patterns (PAMP), MHC…
Keywords Cancer gene therapy, molecular imaging, systemic gene delivery, tumor targeting, vascular targeting, bacteriophage, adeno-associated virus Introduction Gene therapy has attracted considerable attention in the past few decades. One…
Keywords Oncolytic virus, molecular imaging, bioluminescence imaging, fluorescence imaging, PET, SPECT Preclinical Imaging of Viral Gene Expression One important reason for the ongoing and increasing success of oncolytic viruses…
Keywords Gene therapy, clinical trial, FDA, somatic cells Introduction Once a clinical gene therapy target has been identified, it is a lengthy process between proof-of-concept studies and implementation of…
Keywords Lentiviral vector, lentivector, cancer vaccine, gene therapy, immunotherapy, cancer Introduction The immune system likely evolved to fight off disease caused by infections with foreign pathogens. However, it has…
Keywords RNA interference (RNAi), short hairpin RNA (shRNA), ABCD nanoparticle, convection-enhanced delivery (CED), O 6 -methylguanine–DNA methyltransferase (MGMT), malignant glioma, temozolomide (TMZ), genetically modified T cell therapy Introduction Gene…
