Oncohema Key

Keywords Suicide gene, GDEPT, cancer therapy, enzyme prodrug, thymidine kinase, nitroreductase, cytosine deaminase, carboxypeptidase G2, cytochrome P450, bystander effect   Introduction Cancer chemotherapy has had an evolutionary history since the…

Keywords Transkingdom RNAi (tkRNAi), bacteria-mediated RNAi (bmRNAi), RNA-based therapeutics, RNA interference (RNAi), Cancer, Bacteria   Introduction During approximately the past three decades, researchers have been searching for new and improved…

Keywords Viral insertion sites, gene therapy, insertional mutagenesis, lentivial vectors, retroviral vectors, provirus, P140K MGMT   Introduction: Why we Should Know Viral Insertion Sites Cancer gene therapy is an emerging…

Keywords Targeted anti-angiogenic gene therapy, nonviral vector, viral vector, tumor-specific promoter, antibody conjugation, peptide conjugation, adeno-associated virus phage, tumor necrosis factor-α   Introduction The microenvironment in which a tumor originates…

Keywords Cancer, vaccines, poxviruses, TRICOM, immunotherapy, intratumoral vaccination, immunostimulatory molecules, costimulatory molecules   In this chapter, we review the use of recombinant poxviral vectors containing transgenes for costimulatory molecules and…

Keywords FDA, CBER, cancer gene therapy, regulatory review, CMC, pharmacology/toxicology, clinical, drug development   Introduction FDA’s Regulatory Responsibility and Gene Therapy Submissions In the United States, the U.S. Food and…

Keywords MGMT, P140K, chemoprotection, drug-resistance gene therapy, hematopoietic stem cell gene therapy, glioblastoma   Introduction to MGMT Gene Transfer in Cancer Therapeutics The O 6 -methylguanine methyltransferase (MGMT) catalytic protein…

Keywords Sodium iodide symporter (NIS), viral vector, lentivirus, radioiodide, tumor-specific targeting promoter   Sodium Iodide Symporter Thyroid hormone synthesis requires a variety of molecules in thyroid follicular cells, including sodium…