Abstract Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders characterized by varying degrees of cytopenias secondary to ineffective and dysplastic hematopoiesis and increased propensity to evolve into acute myeloid…
Abstract Lymphoproliferative disorders manifest with uncontrolled hyperplasia of lymphoid tissues (lymph nodes, spleen, bone marrow, liver). They are a heterogeneous group of diseases that range from reactive polyclonal hyperplasia (immunologic…
Abstract In this chapter, we introduce the concept of hemolytic anemia and classify them into corpuscular defects due to abnormalities in membrane, enzymes or hemoglobin and extracorpuscular defects due to…
Abstract This chapter describes the physiology of hemostasis including platelet plug formation, platelet vessel interaction, coagulation cascade and fibrinolysis; diagnosis and management of von Willebrand disease; inherited and rare bleeding…
Abstract This chapter describes the causes, clinical manifestatilons, diagnosis, and treatment of various quantitative disorders of white blood cells, both inherited and acquired. It also discusses disorders of white cell…
Abstract This chapter describes the current understanding of a wide variety of platelet pathology, including thrombocytopenia, thrombocytosis, qualitative platelet disorders, and diagnostic approaches to these problems. Autoimmune and alloimmune neonatal…
Abstract This chapter describes the clinical manifestations, diagnosis, complications, and management of sickle cell disease, thalassemia, and other hemoglobinopathies. Keywords Sickle cell disease, thalassemia, anemia, transcranial Doppler ultrasonography, transfusion, chelation…
Abstract The term polycythemia, particularly as it pertains to newborns and children, should be more accurately termed erythrocytosis because it generally refers to conditions in which only erythrocytes are increased…
Abstract This chapter focuses on hemolytic anemia caused by extracorpuscular defects due to immune-mediated hemolytic anemia caused by warm and cold antibodies and nonimmune red cell destruction from acquired and…
Abstract Megaloblastic anemias are characterized by the presence of megaloblasts in the bone marrow and macrocytes in the blood. In more than 95% of cases, megaloblastic anemia is a result…
