Hemostatic Alterations in Liver Disease and Liver Transplantation
SUMMARY Print Section Listen SUMMARY In patients with acute liver failure or chronic liver disease, many changes in the hemostatic system occur. The liver is the site of synthesis of…
Antibody-Mediated Coagulation Factor Deficiencies
SUMMARY Print Section Listen SUMMARY Clinically significant autoantibodies to coagulation factor deficiencies are uncommon but can produce life-threatening bleeding and death. The most commonly targeted coagulation factor in autoimmunity is…
Hereditary Fibrinogen Abnormalities
NOTE Print Section Listen The authors thank Dr. Alessandro Casini for helpful comments and suggestions. SUMMARY Print Section Listen SUMMARY Hereditary fibrinogen abnormalities make up two classes of plasma fibrinogen…
Inherited Deficiencies of Coagulation Factors II, V, V+VIII, VII, X, XI, and XIII
NOTE Print Section Listen The authors would like to thank Dr. U. Selighson and Dr. O. Salomon for their contributions to this chapter. SUMMARY Print Section Listen SUMMARY Rare bleeding…
Acquired Qualitative Platelet Disorders
SUMMARY Print Section Listen SUMMARY Acquired qualitative platelet disorders are frequent causes of abnormal platelet function measured in vitro, although by themselves, they are usually associated with little or no…
Hereditary Qualitative Platelet Disorders
SUMMARY Print Section Listen SUMMARY Abnormalities of platelet function manifest themselves primarily as excessive hemorrhage at mucocutaneous sites, with ecchymoses, petechiae, epistaxis, gingival hemorrhage, and menorrhagia most common. Both quantitative…
Thrombocytopenia
SUMMARY Print Section Listen SUMMARY Thrombocytopenia is one of the most frequent causes for hematologic consultation in the practice of medicine and may be life threatening. Although the normal platelet…
Heparin-Induced Thrombocytopenia
SUMMARY Print Section Listen SUMMARY Heparin-induced thrombocytopenia (HIT) is a prothrombotic complication of treatment with heparin. It is associated with mild-to-moderate thrombocytopenia, although the main clinical concern is the high…
Control of Coagulation Reactions
SUMMARY Print Section Listen SUMMARY The blood coagulation system, like a powerful idling engine, is always active and generating thrombin at very low levels, poised for explosive thrombin generation. Positive…
Vascular Function in Hemostasis
SUMMARY Print Section Listen SUMMARY Blood vessels, especially their endothelial lining, play a critical role in the maintenance of vascular fluidity, arrest of hemorrhage (hemostasis), prevention of occlusive vascular phenomena…
